Vural B, Sofuoglu K, Caliskan E, Delikara N, Aksoy E, Uslu H, Karan A
Kocaeli University, Faculty of Medicine, Department of Obstetrics and Gynecology, Turkey.
Clin Exp Obstet Gynecol. 2005;32(3):158-62.
To find out the predictors of ICSI outcome.
Forty-three pregnancies in 100 consecutive ICSI cycles.
Every 1,000 pg/ml increase in hCG-day E2 (OR = 0.46, CI: 0.25-0.83, p = 0.01) and 1% decrease in the rate of normal sperm morphology (OR = 0.81, CI: 0.67-0.98, p = 0.03) caused a significant decrease in clinical pregnancy rate and live birth rate (respectively, OR = 0.5, CI: 0.32-0.96, p = 0.03, OR = 0.66, CI: 0.5-0.86, p = 0.002) while every increase in the number of good quality embryos transferred caused a two-time increase in the clinical pregnancy rate (OR = 2.1, CI: 1.2-4, p = 0.01). On the other hand, every increase in the number of four-cell cleavage embryos (OR = 1.02, CI: 1.002-1.04, p = 0.03) and hCG-day endometrial thickness (OR = 1.6, CI: 1.15-2.24, p = 0.005) were found to increase the live birth rate. Implantation rate (m = 8.3 +/- 14.6) was significantly lower in cases with leucocytospermia (n = 33) compared to cases without leucocytospermia (n = 67, m = 17.4 +/- 24.6, p = 0.02).
Leucocytospermia, hCG-day E2 level and endometrial thickness, normal sperm morphology, and number of good quality embryos are predictors of implantation, clinical pregnancy and live birth rate following ICSI.
找出卵胞浆内单精子注射（ICSI）结局的预测因素。
100个连续的ICSI周期中有43例妊娠。
人绒毛膜促性腺激素（hCG）日雌二醇（E2）每升高1000 pg/ml（比值比[OR]=0.46，可信区间[CI]：0.25 - 0.83，p = 0.01）以及正常精子形态率每降低1%（OR = 0.81，CI：0.67 - 0.98，p = 0.03），临床妊娠率和活产率均显著降低（分别为OR = 0.5，CI：0.32 - 0.96，p = 0.03；OR = 0.66，CI：0.5 - 0.86，p = 0.002），而优质胚胎移植数量每增加一个，临床妊娠率增加两倍（OR = 2.1，CI：1.2 - 4，p = 0.01）。另一方面，四细胞期分裂胚胎数量每增加一个（OR = 1.02，CI：1.002 - 1.04，p = 0.03）以及hCG日子宫内膜厚度每增加（OR = 1.6，CI：1.15 - 2.24，p = 0.005），活产率增加。与无白细胞精子症的病例（n = 67，均值m = 17.4 ± 24.6）相比，白细胞精子症病例（n = 33）的着床率（m = 8.3 ± 14.6）显著降低（p = 0.02）。
白细胞精子症、hCG日E2水平、子宫内膜厚度、正常精子形态以及优质胚胎数量是ICSI后着床、临床妊娠和活产率的预测因素。
