Kaya Zeynettin, Ulucan Seref, Akyurek Omer, Katlandur Huseyin, Keser Ahmet, Efe Duran, Ozdil Huseyin, Ulgen Mehmet S
Department of Cardiology, Mevlana University, Yeni İstanbul Cad. No: 235, 42003, Selçuklu, Konya, Turkey,
Wien Klin Wochenschr. 2015 Mar;127(5-6):191-6. doi: 10.1007/s00508-015-0722-x. Epub 2015 Mar 13.
The study aimed to examine the association between thoracic periaortic fat tissue volume and the long-term incidence of major adverse cardiovascular events.
This retrospective cohort study included 433 consecutive patients (372 male and 61 female). Periaortic fat tissue volume was measured via electrocardiogram-gated 64-multidetector computed tomography. The patients were evaluated on an average 3 years of follow-up for major adverse cardiovascular events. The patients were divided into groups according to the presence of major adverse cardiovascular events.
Major adverse cardiovascular events were noted in 44 (10.2 %) patients during follow-up. Periaortic fat tissue volume was significantly higher in the major adverse cardiovascular events (+) group (35.4 ± 26.1 cm(3) vs. 24.1 ± 14.9 cm(3), P = 0.001). The logistic regression model showed that periaortic fat tissue volume (hazard ratio: 1.03; 95 % CI: 1.01-1.05; P = 0.001), the glomerular filtration rate (hazard ratio: 0.98; 95 % CI: 0.96-0.99; P = 0.03), and male gender (hazard ratio: 4.76; 95 % CI: 1.08-20.90; P = 0.04) were independent predictors of major adverse cardiovascular events.
Thoracic periaortic fat tissue volume may be considered a useful new parameter for predicting major adverse cardiovascular events.
本研究旨在探讨胸主动脉周围脂肪组织体积与主要不良心血管事件长期发生率之间的关联。
这项回顾性队列研究纳入了433例连续患者（372例男性和61例女性）。通过心电图门控64层螺旋计算机断层扫描测量主动脉周围脂肪组织体积。对患者进行平均3年的随访，以评估主要不良心血管事件。根据是否发生主要不良心血管事件将患者分组。
随访期间44例（10.2%）患者发生主要不良心血管事件。主要不良心血管事件（+）组的主动脉周围脂肪组织体积显著更高（35.4±26.1cm³对24.1±14.9cm³，P=0.001）。逻辑回归模型显示，主动脉周围脂肪组织体积（风险比：1.03；95%可信区间：1.01-1.05；P=0.001）、肾小球滤过率（风险比：0.98；95%可信区间：0.96-0.99；P=0.03）和男性性别（风险比：4.76；95%可信区间：1.08-20.90；P=0.04）是主要不良心血管事件的独立预测因素。
胸主动脉周围脂肪组织体积可被视为预测主要不良心血管事件的一个有用的新参数。
