使用可移除连接基的钌催化吲哚的杂原子导向区域选择性C-H芳基化反应
Ruthenium-catalyzed heteroatom-directed regioselective C-H arylation of indoles using a removable tether.
作者信息
Tiwari Virendra Kumar, Kamal Neha, Kapur Manmohan
机构信息
Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Indore Bypass Road, Bhauri, Bhopal 462066, India.
出版信息
Org Lett. 2015 Apr 3;17(7):1766-9. doi: 10.1021/acs.orglett.5b00535. Epub 2015 Mar 12.
A new approach to C-2 arylated indoles has been developed by utilizing a ruthenium-catalyzed, heteroatom-directed regioselective C-H arylation. The reaction is highly site-selective and results in very good yields. The highlight of the work is the use of a removable directing group and compatibility of the catalytic system with halogen functional groups in the substrates.
通过利用钌催化的、杂原子导向的区域选择性C-H芳基化反应，开发了一种合成C-2芳基吲哚的新方法。该反应具有高度的位点选择性，产率很高。这项工作的亮点在于使用了一个可去除的导向基团以及催化体系与底物中卤素官能团的兼容性。
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