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钌催化、以烯丙醇作为偶联伙伴的吲哚的位点选择性C-H烯丙基化反应

Ruthenium-Catalyzed, Site-Selective C-H Allylation of Indoles with Allyl Alcohols as Coupling Partners.

作者信息

Kumar Gangam Srikanth, Kapur Manmohan

机构信息

Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal Bypass Road, Bhauri, Bhopal 462066, India.

出版信息

Org Lett. 2016 Mar 4;18(5):1112-5. doi: 10.1021/acs.orglett.6b00217. Epub 2016 Feb 19.

DOI:10.1021/acs.orglett.6b00217
PMID:26894585
Abstract

A new ruthenium-catalyzed, heteroatom-directed strategy for C-H allylation of indoles is described. The use of allyl alcohols as coupling partners as well as pyridine as the removable directing group is highlighted. This methodology provides access to C2-allylated indoles by utilizing a strategy that does not require prefunctionalization of either of the coupling partners.

摘要

本文描述了一种新型的钌催化、杂原子导向的吲哚C-H烯丙基化策略。重点介绍了使用烯丙醇作为偶联伙伴以及吡啶作为可去除导向基团。该方法通过一种无需对偶联伙伴进行预官能化的策略实现了C2-烯丙基化吲哚的合成。

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