Dansako Hiromichi, Kato Nobuyuki
Nihon Rinsho. 2015 Feb;73(2):229-33.
In the viral reproduction, hepatitis C virus(HCV) produces double-stranded RNA (dsRNA) as a replication intermediate. RIG-I(retinoic acid inducible protein I) recognizes the intracellular HCV dsRNA as a "non self" molecule, and triggers the induction of interferon (IFN)-β and then numerous IFN-stimulated genes(ISGs). On the other hand, one of toll-like receptors, TLR3 also recognizes the extracellular HCV dsRNA, and subsequently triggers the induction of IFN-β and ISGs. We recently reported class A scavenger receptor (MSR1) was required for TLR3-mediated recognition of the extracellular HCV dsRNA. In this review, we summarize current knowledge about RIG-I- and TLR3/MSR1-mediated recognition mechanisms of HCV infection.
在病毒复制过程中，丙型肝炎病毒（HCV）产生双链RNA（dsRNA）作为复制中间体。视黄酸诱导蛋白I（RIG-I）将细胞内的HCV dsRNA识别为“非自身”分子，并触发干扰素（IFN）-β的诱导，进而诱导众多干扰素刺激基因（ISG）。另一方面，Toll样受体之一的TLR3也识别细胞外的HCV dsRNA，随后触发IFN-β和ISG的诱导。我们最近报道，A类清道夫受体（MSR1）是TLR3介导的对细胞外HCV dsRNA识别所必需的。在本综述中，我们总结了目前关于RIG-I以及TLR3/MSR1介导的HCV感染识别机制的知识。
