Vorozhtsova S V, Abrosimova A N, Kulikova E I, Dorozhkina O V, Kovalenko M A, Kriuchkova D M, Severiukhin Iu S, Gaevskiĭ V N, Siniak Iu E, Ivanov A A
Radiats Biol Radioecol. 2014 Jan-Feb;54(1):21-6.
The influence of light water with the reduced content of heavy stable isotopes of oxygen and hydrogen (deuterium) on the cytogenetic status of irradiated animals was investigated. In mice, hybrids of the first generation (CBA x C57B1) F1, the increase in the output (two-fold at the dose of 2 Gy) of aberrant mitoses in the cells of bone marrow and the decrease in the duration of the mitotic index of the first cellular cycle occurred under the influence of the two week maintenance before the irradiation on light water with ppm 35 obtained by the method of rectification as compared with the irradiated animals that were kept on the distilled water. It has been discovered that 24 h after irradiation the number of leukocytes in the group which consumed light water is lower than that in the animals that were contained on the distilled water. Moreover, the cellularity of the bone marrow in the group which consumed light water was higher than that in the animals that were contained on distilled water. The prolonged application of light water before irradiation (for 14 days) led to an increase in the sensitivity of the chromosomal apparatus of mice to γ-irradiation against the background of an increase in the mitotic activity of cells.
研究了重稳定氧和氢（氘）同位素含量降低的轻水对受辐照动物细胞遗传状态的影响。在第一代杂种小鼠（CBA×C57B1）F1中，与饮用蒸馏水的受辐照动物相比，在通过精馏法获得的百万分之35的轻水饲养两周后再进行辐照的情况下，骨髓细胞中异常有丝分裂的产出增加（2 Gy剂量时增加两倍），且第一个细胞周期的有丝分裂指数持续时间缩短。已发现辐照后24小时，饮用轻水组的白细胞数量低于饮用蒸馏水的动物。此外，饮用轻水组的骨髓细胞密度高于饮用蒸馏水的动物。辐照前长期饮用轻水（14天）导致在细胞有丝分裂活性增加的背景下，小鼠染色体装置对γ辐照的敏感性增加。
