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FOXRED1的结构模型，FOXRED1是NADH：泛醌氧化还原酶（复合体I）组装所必需的一种依赖黄素腺嘌呤二核苷酸的氧化还原酶。

A structural model for FOXRED1, an FAD-dependent oxidoreductase necessary for NADH: Ubiquinone oxidoreductase (complex I) assembly.

作者信息

Lemire Bernard D

机构信息

Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.

出版信息

Mitochondrion. 2015 May;22:9-16. doi: 10.1016/j.mito.2015.02.008. Epub 2015 Mar 9.

DOI:10.1016/j.mito.2015.02.008
PMID:25765152
Abstract

The biogenesis of mitochondrial respiratory chain components is complex. Mammalian complex I (NADH:ubiquinone oxidoreductase) contains 44 different subunits, an FMN and seven iron-sulfur centers. Its assembly involves at least twelve additional proteins, called assembly factors. One of these is FOXRED1, a 486-amino acid FAD-dependent oxidoreductase. FOXRED1 is a member of the d-amino acid oxidase (DAO) family. A structural model of FOXRED1 reveals a large substrate-binding cavity and a putative oxygen-binding site. These features strongly suggest that FOXRED1 is catalytically active as an oxidoreductase. A metabolic role for FOXRED1 in the biogenesis of complex I should be considered.

摘要

线粒体呼吸链组分的生物合成过程很复杂。哺乳动物的复合体I（NADH：泛醌氧化还原酶）包含44个不同的亚基、一个FMN和七个铁硫中心。其组装过程至少涉及另外12种蛋白质，即组装因子。其中之一是FOXRED1，一种含486个氨基酸的FAD依赖性氧化还原酶。FOXRED1是d-氨基酸氧化酶（DAO）家族的成员。FOXRED1的结构模型显示出一个大的底物结合腔和一个假定的氧结合位点。这些特征强烈表明FOXRED1作为氧化还原酶具有催化活性。应考虑FOXRED1在复合体I生物合成中的代谢作用。

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FOXRED1 silencing in mice: a possible animal model for Leigh syndrome.沉默 FOXRED1 基因的小鼠： Leigh 综合征的可能动物模型。
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