Hardeveld Florian, Spijker Jan, Peyrot Wouter J, de Graaf Ron, Hendriks Sanne M, Nolen Willem A, Penninx Brenda W J H, Beekman Aartjan T F
Pro Persona, Institute for Mental Health Care, PO Box 70, 6710 RR Ede, The Netherlands.
Pro Persona, Institute for Mental Health Care, PO Box 70, 6710 RR Ede, The Netherlands; Netherlands Institute of Mental Health and Addiction, PO Box 725, 3500 AS Utrecht, The Netherlands; Behavioral Science Institute, Radboud University Nijmegen, PO Box 9104, 6500 HE Nijmegen, The Netherlands.
Psychoneuroendocrinology. 2015 May;55:154-63. doi: 10.1016/j.psyneuen.2015.02.013. Epub 2015 Feb 26.
Previous research found that variants of the glucocorticoid receptor (GR) (9β, ER22/23EK, BclI, TthIIIl, NR3C1-1 and N363S) and mineralocorticoid receptor (MR) gene polymorphism (-2 C/G and I180V) are associated with both glucocorticoid (GC) sensitivity and major depressive disorder (MDD). There are no data which investigated prospectively whether these variants are associated with recurrence of MDD.
Data were derived from the Netherlands Study of Depression and Anxiety (NESDA) which used the Composite International Diagnostic Interview (CIDI) to determine MDD. Polymorphisms in the GR and MR gene were determined and haplotypes were characterized. We analyzed in retrospect whether recurrent MDD (n=951) in comparison with first onset MDD (n=919) was associated with polymorphisms in the GR and MR gene. Furthermore, we analyzed prospectively for 4 years the time to recurrence among 683 subjects with a remitted MDD diagnosis. Time to recurrence of MDD was assessed using the CIDI and a life chart interview. Additionally, we analyzed interactions of the investigated polymorphisms with childhood trauma and recent negative life events.
GR and MR gene polymorphisms and derived haplotypes were not associated with recurrence of depression in both retrospective and prospective analyses. In addition, no consistent interactions between GR and MR polymorphisms and childhood trauma or life events were found.
This study did not find consistent associations between GR and MR gene polymorphisms, interactions between GR and MR haplotypes and stressful conditions and recurrence of MDD.
先前的研究发现，糖皮质激素受体（GR）的变体（9β、ER22/23EK、BclI、TthIIIl、NR3C1-1和N363S）以及盐皮质激素受体（MR）基因多态性（-2 C/G和I180V）与糖皮质激素（GC）敏感性和重度抑郁症（MDD）均相关。尚无数据前瞻性地研究这些变体是否与MDD的复发有关。
数据来自荷兰抑郁与焦虑研究（NESDA），该研究使用复合国际诊断访谈（CIDI）来确定MDD。确定了GR和MR基因中的多态性并对单倍型进行了特征分析。我们回顾性分析了复发性MDD（n = 951）与首次发作的MDD（n = 919）相比是否与GR和MR基因中的多态性相关。此外，我们对683名已缓解MDD诊断的受试者进行了4年的前瞻性复发时间分析。使用CIDI和生活图表访谈评估MDD的复发时间。此外，我们分析了所研究的多态性与童年创伤和近期负面生活事件之间的相互作用。
在回顾性和前瞻性分析中，GR和MR基因多态性及衍生的单倍型均与抑郁症复发无关。此外，未发现GR和MR多态性与童年创伤或生活事件之间存在一致的相互作用。
本研究未发现GR和MR基因多态性、GR和MR单倍型之间的相互作用与应激条件及MDD复发之间存在一致的关联。
