Division of Psychology, School of Humanities and Social Sciences, Nanyang Technological University, 14 Nanyang Drive, Singapore 637332, Singapore.
Department of General Psychiatry, Institute of Mental Health, 10 Buangkok View, Singapore 539747, Singapore.
Neurosci Biobehav Rev. 2015 May;52:233-57. doi: 10.1016/j.neubiorev.2015.03.002. Epub 2015 Mar 10.
Obsessive-compulsive disorder (OCD) is a debilitating disorder. However, existing neuroimaging findings involving executive function and structural abnormalities in OCD have been mixed. Here we conducted meta-analyses to investigate differences in OCD samples and controls in: Study 1 - grey matter structure; Study 2 - executive function task-related activations during (i) response inhibition, (ii) interference, and (iii) switching tasks; and Study 3 - white matter diffusivity. Results showed grey matter differences in the frontal, striatal, thalamus, parietal and cerebellar regions; task domain-specific neural differences in similar regions; and abnormal diffusivity in major white matter regions in OCD samples compared to controls. Our results reported concurrence of abnormal white matter diffusivity with corresponding abnormalities in grey matter and task-related functional activations. Our findings suggested the involvement of other brain regions not included in the cortico-striato-thalamo-cortical network, such as the cerebellum and parietal cortex, and questioned the involvement of the orbitofrontal region in OCD pathophysiology. Future research is needed to clarify the roles of these brain regions in the disorder.
强迫症（OCD）是一种使人衰弱的疾病。然而，现有的涉及 OCD 中执行功能和结构异常的神经影像学研究结果并不一致。在这里，我们进行了荟萃分析，以研究 OCD 样本和对照组之间的差异：研究 1-灰质结构；研究 2-执行功能任务相关激活，包括（i）反应抑制、（ii）干扰和（iii）切换任务；研究 3-白质扩散。结果显示，OCD 样本和对照组在额叶、纹状体、丘脑、顶叶和小脑区域的灰质结构存在差异；在类似区域，任务域特定的神经差异；与对照组相比，OCD 样本的主要白质区域的扩散异常。我们的研究结果报告了白质扩散异常与灰质和任务相关功能激活的对应异常的一致性。我们的发现表明，小脑和顶叶皮层等皮质-纹状体-丘脑-皮质网络以外的其他脑区可能参与了 OCD 的病理生理学过程，而眶额皮层区域是否参与其中仍存在争议。需要进一步的研究来阐明这些脑区在该疾病中的作用。
