From the Department of Pharmacology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France (S.L., P.B.); Université Paris-Descartes, Paris, France (S.L., P.B.); and INSERM U 970, Paris, France (S.L., P.B.).
Circ Res. 2015 Mar 13;116(6):1007-21. doi: 10.1161/CIRCRESAHA.116.303596.
Pathophysiological studies have extensively investigated the structural factor in hypertension, including large and small artery remodeling and functional changes. Here, we review the recent literature on the alterations in small and large arteries in hypertension. We discuss the possible mechanisms underlying these abnormalities and we explain how they accompany and often precede hypertension. Finally, we propose an integrated pathophysiological approach to better understand how the cross-talk between large and small artery changes interacts in pressure wave transmission, exaggerates cardiac, brain and kidney damage, and lead to cardiovascular and renal complications. We focus on patients with essential hypertension because this is the most prevalent form of hypertension, and describe other forms of hypertension only for contrasting their characteristics with those of uncomplicated essential hypertension.
病理生理学研究已经广泛研究了高血压的结构因素，包括大动脉和小动脉的重塑和功能变化。在这里，我们综述了高血压中小动脉和大动脉改变的最新文献。我们讨论了这些异常的潜在机制，并解释了它们如何伴随并常常先于高血压发生。最后，我们提出了一种综合的病理生理学方法，以更好地理解大、小动脉变化之间的相互作用如何在压力波传递中相互影响，放大心脏、大脑和肾脏的损伤，并导致心血管和肾脏并发症。我们重点关注原发性高血压患者，因为这是最常见的高血压形式，并仅描述了其他形式的高血压，以便将其特征与单纯原发性高血压的特征进行对比。
