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从九里香中分离得到的戈里宁宾的体外和体内抗血管生成活性

In vitro and in vivo anti-angiogenic activity of girinimbine isolated from Murraya koenigii.

作者信息

Iman Venoos, Karimian Hamed, Mohan Syam, Hobani Yahya Hasan, Noordin Mohamed Ibrahim, Mustafa Mohd Rais, Noor Suzita Mohd

机构信息

Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Medical Research Center, University of Jazan, Jazan, Saudi Arabia.

出版信息

Drug Des Devel Ther. 2015 Mar 3;9:1281-92. doi: 10.2147/DDDT.S71557. eCollection 2015.

DOI:10.2147/DDDT.S71557
PMID:25767375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4354401/
Abstract

Girinimbine is a carbazole alkaloid isolated from the stem bark and root of Murraya koenigii. Here we report that girinimbine is an inhibitor of angiogenic activity both in vitro and in vivo. MTT results showed that girinimbine inhibited proliferation of human umbilical vein endothelial cells, while results from endothelial cell invasion, migration, tube formation, and wound healing assays demonstrated significant time- and dose-dependent inhibition by girinimbine. A proteome profiler array done on girinimbine-treated human umbilical vein endothelial cells showed that girinimbine had mediated regulation of pro-angiogenic and anti-angiogenic proteins. The anti-angiogenic potential of girinimbine was also evidenced in vivo in the zebrafish embryo model wherein girinimbine inhibited neo vessel formation in zebrafish embryos following 24 hours of exposure. Together, these results showed that girinimbine could effectively suppress angiogenesis, suggestive of its therapeutic potential as a novel angiogenesis inhibitor.

摘要

柯楠碱是一种从印度楝的茎皮和根中分离出来的咔唑生物碱。在此我们报告，柯楠碱在体外和体内均为血管生成活性的抑制剂。MTT结果显示，柯楠碱抑制人脐静脉内皮细胞的增殖，而内皮细胞侵袭、迁移、管腔形成和伤口愈合试验的结果表明，柯楠碱具有显著的时间和剂量依赖性抑制作用。对经柯楠碱处理的人脐静脉内皮细胞进行的蛋白质组分析阵列显示，柯楠碱介导了促血管生成和抗血管生成蛋白的调节。柯楠碱的抗血管生成潜力在斑马鱼胚胎模型中也得到了证实，在该模型中，暴露24小时后，柯楠碱抑制了斑马鱼胚胎中的新血管形成。总之，这些结果表明，柯楠碱可以有效抑制血管生成，提示其作为一种新型血管生成抑制剂的治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aef/4354401/dbb98c9abb72/dddt-9-1281Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aef/4354401/77d77f9e35c8/dddt-9-1281Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aef/4354401/ce580e064a43/dddt-9-1281Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aef/4354401/8ca4aff5b8d6/dddt-9-1281Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aef/4354401/e2c765e16e4e/dddt-9-1281Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aef/4354401/b52144d17928/dddt-9-1281Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aef/4354401/e9c0389e954b/dddt-9-1281Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aef/4354401/dbb98c9abb72/dddt-9-1281Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aef/4354401/77d77f9e35c8/dddt-9-1281Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aef/4354401/ce580e064a43/dddt-9-1281Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aef/4354401/8ca4aff5b8d6/dddt-9-1281Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aef/4354401/e2c765e16e4e/dddt-9-1281Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aef/4354401/b52144d17928/dddt-9-1281Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aef/4354401/e9c0389e954b/dddt-9-1281Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aef/4354401/dbb98c9abb72/dddt-9-1281Fig7.jpg

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本文引用的文献

1
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Front Physiol. 2014 Mar 28;5:114. doi: 10.3389/fphys.2014.00114. eCollection 2014.
2
Cytokines and angiogenesis in the corpus luteum.黄体中的细胞因子与血管生成。
Mediators Inflamm. 2013;2013:420186. doi: 10.1155/2013/420186. Epub 2013 Jun 11.
3
Apoptosis Effect of Girinimbine Isolated from Murraya koenigii on Lung Cancer Cells In Vitro.从九里香中分离出的醉鱼草宁碱对肺癌细胞的体外凋亡作用。
β-石竹烯诱导结直肠癌细胞凋亡和抑制血管生成。
Int J Mol Sci. 2021 Sep 29;22(19):10550. doi: 10.3390/ijms221910550.
4
Apatinib as targeted therapy for sarcoma.阿帕替尼作为肉瘤的靶向治疗药物。
Oncotarget. 2018 May 11;9(36):24548-24560. doi: 10.18632/oncotarget.24647.
5
Combination therapy of apatinib with icotinib for primary acquired icotinib resistance in patients with advanced pulmonary adenocarcinoma with EGFR mutation.阿帕替尼联合伊可替尼治疗 EGFR 突变晚期肺腺癌患者获得性伊可替尼耐药的初步研究
Thorac Cancer. 2018 May;9(5):656-661. doi: 10.1111/1759-7714.12624. Epub 2018 Mar 24.
6
Anticancer and anti-inflammatory activities of girinimbine isolated from .从……中分离得到的柯里拉京的抗癌和抗炎活性。 （原句不完整，此译文按补充完整后的逻辑翻译）
Drug Des Devel Ther. 2016 Dec 28;11:103-121. doi: 10.2147/DDDT.S115135. eCollection 2017.
7
Apatinib for molecular targeted therapy in tumor.阿帕替尼用于肿瘤的分子靶向治疗。
Drug Des Devel Ther. 2015 Nov 13;9:6075-81. doi: 10.2147/DDDT.S97235. eCollection 2015.
Evid Based Complement Alternat Med. 2013;2013:689865. doi: 10.1155/2013/689865. Epub 2013 Mar 13.
4
The role of IL-1β in the early tumor cell-induced angiogenic response.IL-1β 在早期肿瘤细胞诱导的血管生成反应中的作用。
J Immunol. 2013 Apr 1;190(7):3500-9. doi: 10.4049/jimmunol.1202769. Epub 2013 Mar 8.
5
Angiopoietins in angiogenesis.血管生成素在血管生成中的作用。
Cancer Lett. 2013 Jan 1;328(1):18-26. doi: 10.1016/j.canlet.2012.08.018. Epub 2012 Aug 23.
6
In vitro and in vivo anti-angiogenic activities of Panduratin A.Panduratin A 的体外和体内抗血管生成活性。
PLoS One. 2012;7(5):e38103. doi: 10.1371/journal.pone.0038103. Epub 2012 May 30.
7
Biological activity of carbazole alkaloids and essential oil of Murraya koenigii against antibiotic resistant microbes and cancer cell lines.咔唑生物碱和九里香精油对耐药微生物和癌细胞系的生物活性。
Molecules. 2011 Nov 21;16(11):9651-64. doi: 10.3390/molecules16119651.
8
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Molecules. 2011 Aug 23;16(8):7155-70. doi: 10.3390/molecules16087155.
9
MCP-1: chemoattractant with a role beyond immunity: a review.单核细胞趋化蛋白 1：超越免疫作用的趋化因子：综述。
Clin Chim Acta. 2010 Nov 11;411(21-22):1570-9. doi: 10.1016/j.cca.2010.07.006. Epub 2010 Jul 13.
10
Rosuvastatin, identified from a zebrafish chemical genetic screen for antiangiogenic compounds, suppresses the growth of prostate cancer.瑞舒伐他汀是从斑马鱼抗血管生成化合物的化学遗传筛选中鉴定出来的，可抑制前列腺癌的生长。
Eur Urol. 2010 Sep;58(3):418-26. doi: 10.1016/j.eururo.2010.05.024. Epub 2010 May 22.