阿地芬诺酯对不同大鼠脑结构单胺氧化酶体外活性的影响。
Effect of adafenoxate on different rat brain structures monoamine oxidase activity in vitro.
作者信息
Stancheva S, Kunova P
机构信息
Department of Experimental Pharmacology, Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1989;94(1):41-4. doi: 10.1016/0742-8413(89)90141-2.
PMID:2576744
Abstract
- The effect of the nootropic drug adafenoxate on monoamine oxidase (MAO) activity in rat brain cortex, striatum, hypothalamus and hippocampus has been studied using the following substrates: tyramine (total MAO), serotonin (MAO A) and beta-phenylethylamine (MAO B). 2. In a series of increased concentrations (from 5 x 10(-4) up to 1 x 10(-5) M) adafenoxate inhibits total MAO, MAO A and MAO B in the brain structures studied. 3. The adafenoxate IC50 values obtained illustrate its inhibitory properties and its lack of selectivity toward MAO in the brain structures isolated. 4. The results of our research prove the participation of MAO in the mechanisms through which adafenoxate affects the brain monoaminergic systems and realises its central effects.
摘要
- 已使用以下底物研究了促智药阿屈非尼对大鼠大脑皮层、纹状体、下丘脑和海马体中单胺氧化酶（MAO）活性的影响：酪胺（总MAO）、5-羟色胺（MAO A）和β-苯乙胺（MAO B）。2. 在一系列浓度增加的情况下（从5×10⁻⁴到1×10⁻⁵M），阿屈非尼抑制所研究脑结构中的总MAO、MAO A和MAO B。3. 所获得的阿屈非尼IC50值表明了其抑制特性以及对分离出的脑结构中MAO缺乏选择性。4. 我们的研究结果证明MAO参与了阿屈非尼影响大脑单胺能系统并实现其中枢效应的机制。
相似文献
1
Effect of adafenoxate on different rat brain structures monoamine oxidase activity in vitro.阿地芬诺酯对不同大鼠脑结构单胺氧化酶体外活性的影响。
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1989;94(1):41-4. doi: 10.1016/0742-8413(89)90141-2.
2
[Effect of centrophenoxine, piracetam and aniracetam on the monoamine oxidase activity in different brain structures of rats].[盐酸甲氯芬酯、吡拉西坦和茴拉西坦对大鼠不同脑区单胺氧化酶活性的影响]
Farmakol Toksikol. 1988 May-Jun;51(3):16-8.
3
In vitro and in vivo effect of the nootropic agent adafenoxate on the 5-HT1 sites in different rat brain structures.促智药阿屈非尼对不同大鼠脑结构中5-HT1位点的体外和体内作用
Gen Pharmacol. 1994 Sep;25(5):977-9. doi: 10.1016/0306-3623(94)90106-6.
4
Changes in brain biogenic monoamines induced by the nootropic drugs adafenoxate and meclofenoxate and by citicholine (experiments on rats).益智药阿屈非尼和氯酯醒以及胞磷胆碱对大鼠脑生物源性单胺的影响（实验研究）
Gen Pharmacol. 1990;21(1):71-5. doi: 10.1016/0306-3623(90)90598-g.
5
Effects of the nootropic agents adafenoxate and meclofenoxate on brain biogenic monoamines in aged rats.促智药阿屈非尼和氯苯氧胺对老年大鼠脑内生物源性单胺的影响。
Acta Physiol Pharmacol Bulg. 1988;14(1):14-21.
6
Biogenic monoamine uptake by rat brain synaptosomes during aging. Effects of nootropic drugs.
Gen Pharmacol. 1994 Sep;25(5):981-7. doi: 10.1016/0306-3623(94)90107-4.
7
Age-related changes of cyclic AMP phosphodiesterase activity in rat brain regions and a new phosphodiesterase inhibitor--nootropic agent adafenoxate.大鼠脑区环磷酸腺苷磷酸二酯酶活性的年龄相关性变化及一种新型磷酸二酯酶抑制剂——促智药阿屈非尼
Gen Pharmacol. 1991;22(5):955-8. doi: 10.1016/0306-3623(91)90237-z.
8
9
Comparative studies on the effects of the nootropic drug adafenoxate and of the cerebral vasodilator flunarizine on arterial smooth muscles.
Acta Physiol Pharmacol Bulg. 1988;14(3):10-6.
10
Selective inhibition by 4,alpha-dimethyl-m-tyramine (H77/77) and 4-methyl-alpha-ethyl-m-tyramine (H75/12) of the monoamine oxidase within serotonergic and noradrenergic neurons in the rat brain.4,α-二甲基间酪氨酸（H77/77）和4-甲基-α-乙基间酪氨酸（H75/12）对大鼠脑中5-羟色胺能和去甲肾上腺素能神经元内单胺氧化酶的选择性抑制作用。
Naunyn Schmiedebergs Arch Pharmacol. 1988 Aug;338(2):143-7. doi: 10.1007/BF00174862.
Zotero 插件