益智药阿屈非尼和氯酯醒以及胞磷胆碱对大鼠脑生物源性单胺的影响（实验研究）

Changes in brain biogenic monoamines induced by the nootropic drugs adafenoxate and meclofenoxate and by citicholine (experiments on rats).

Petkov V D, Stancheva S L, Tocuschieva L, Petkov V V

Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia.

Gen Pharmacol. 1990;21(1):71-5. doi: 10.1016/0306-3623(90)90598-g.

Abstract

The effects of Adafenoxate (Adf), meclofenoxate (Mf) and citicholine (CCh) administered at a daily dose of 100 mg/kg for 7 days on the levels of noradrenaline (NA), dopamine (DA) and serotonin (5-HT) in the frontal cerebral cortex, striatum, hippocampus and hypothalamus of rats were studied. 2. Adafenoxate increased the NA level in the striatum and decreased it in the hypothalamus; it increased the DA level in the cerebral cortex and hypothalamus and decreased it in the striatum; it increased the 5-HT level in the cerebral cortex and decreased it in the hippocampus. 3. Meclofenoxate decreased the NA level in the cerebral cortex and hypothalamus; it increased the DA level in the hippocampus and hypothalamus and the 5-HT level in the cerebral cortex, striatum, hippocampus and hypothalamus. 4. Citicholine increased the NA level in the cerebral cortex and hypothalamus; it increased the DA level in the striatum and the 5-HT level in the cerebral cortex, striatum and hippocampus. 5. An attempt is made to explain some similarities and differences in the behavioral effects of the drugs tested (and those observed in other studies) by the changes they induce in brain biogenic monoamines.

摘要

研究了每日以100毫克/千克的剂量给予大鼠阿屈非尼（Adf）、甲氯芬酯（Mf）和胞磷胆碱（CCh）7天，对大鼠额叶皮质、纹状体、海马体和下丘脑去甲肾上腺素（NA）、多巴胺（DA）和5-羟色胺（5-HT）水平的影响。2. 阿屈非尼使纹状体中的NA水平升高，使下丘脑中的NA水平降低；它使大脑皮质和下丘脑中的DA水平升高，使纹状体中的DA水平降低；它使大脑皮质中的5-HT水平升高，使海马体中的5-HT水平降低。3. 甲氯芬酯使大脑皮质和下丘脑中的NA水平降低；它使海马体和下丘脑中的DA水平升高，使大脑皮质、纹状体、海马体和下丘脑中的5-HT水平升高。4. 胞磷胆碱使大脑皮质和下丘脑中的NA水平升高；它使纹状体中的DA水平升高，使大脑皮质、纹状体和海马体中的5-HT水平升高。5. 尝试通过所测试药物（以及其他研究中观察到的药物）引起的脑生物源性单胺变化来解释它们行为效应中的一些异同。