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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Alvinerie M, Tufenkji A E, Houin G, Toutain P L, Galtier P

Laboratoire de Pharmacologie-Toxicologie, Institut National de la Recherche Agronomique, Toulouse, France.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1989;94(1):81-6. doi: 10.1016/0742-8413(89)90147-3.

The kinetics of intravenously administered prednisone (0.5 mg/kg) and methylprednisolone hemisuccinate (4 mg/kg) were compared in two groups of four young male sheep before and regularly after experimental infestation with 150 metacercariae of Fasciola hepatica and 5 or 7 weeks following a flukicidal treatment administered post-infection at week 25. 2. Parasitic pathology was ascertained by clinical observation and by the increase in plasma antibodies directed against liver flukes. 3. The disposition of prednisone was altered with a significant decrease of plasma clearance occurring from eleven weeks after infection onwards. This change was parallel to an increase in the mean residence time of prednisone and of its major metabolite (prednisolone). 4. The same parasitic burden provoked only a slight decrease in the elimination half-life of methylprednisolone alcohol when its hemisuccinate ester was administered.

在两组各四只年轻雄性绵羊中，比较了静脉注射泼尼松（0.5毫克/千克）和半琥珀酸甲泼尼龙（4毫克/千克）的动力学，一组在感染150只肝片吸虫囊蚴之前及之后定期观察，另一组在感染后第25周进行杀吸虫治疗后5或7周观察。2. 通过临床观察和针对肝吸虫的血浆抗体增加来确定寄生虫病理学。3. 感染后11周起，泼尼松的处置发生改变，血浆清除率显著降低。这种变化与泼尼松及其主要代谢物（泼尼松龙）的平均驻留时间增加平行。4. 当给予半琥珀酸甲泼尼龙酯时，相同的寄生虫负荷仅使甲泼尼龙醇的消除半衰期略有降低。

Alvinerie M, Tufenkji A E, Houin G, Toutain P L, Galtier P

Laboratoire de Pharmacologie-Toxicologie, Institut National de la Recherche Agronomique, Toulouse, France.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1989;94(1):81-6. doi: 10.1016/0742-8413(89)90147-3.

The kinetics of intravenously administered prednisone (0.5 mg/kg) and methylprednisolone hemisuccinate (4 mg/kg) were compared in two groups of four young male sheep before and regularly after experimental infestation with 150 metacercariae of Fasciola hepatica and 5 or 7 weeks following a flukicidal treatment administered post-infection at week 25. 2. Parasitic pathology was ascertained by clinical observation and by the increase in plasma antibodies directed against liver flukes. 3. The disposition of prednisone was altered with a significant decrease of plasma clearance occurring from eleven weeks after infection onwards. This change was parallel to an increase in the mean residence time of prednisone and of its major metabolite (prednisolone). 4. The same parasitic burden provoked only a slight decrease in the elimination half-life of methylprednisolone alcohol when its hemisuccinate ester was administered.

在两组各四只年轻雄性绵羊中，比较了静脉注射泼尼松（0.5毫克/千克）和半琥珀酸甲泼尼龙（4毫克/千克）的动力学，一组在感染150只肝片吸虫囊蚴之前及之后定期观察，另一组在感染后第25周进行杀吸虫治疗后5或7周观察。2. 通过临床观察和针对肝吸虫的血浆抗体增加来确定寄生虫病理学。3. 感染后11周起，泼尼松的处置发生改变，血浆清除率显著降低。这种变化与泼尼松及其主要代谢物（泼尼松龙）的平均驻留时间增加平行。4. 当给予半琥珀酸甲泼尼龙酯时，相同的寄生虫负荷仅使甲泼尼龙醇的消除半衰期略有降低。