Tufenkji A E, Alvinerie M, Houin G, Galtier P
Station de Pharmacologie-Toxicologie, INRA, Toulouse, France.
Res Vet Sci. 1987 Nov;43(3):327-30.
The pharmacokinetics of three drugs proposed for the assessment of liver function: sulphobromophthalein (BSP), lidocaine and indocyanine green (ICG) were determined in sheep four, eight, 12, 16 and 24 weeks after their infestation by an oral administration of 150 metacercariae of Fasciola hepatica. The disposition of BSP was altered by a significant decrease in its total plasma clearance from eight weeks after infection onwards. This change could be related to the low values of the elimination rate constant consistent with a reduced liver cytosolic conjugation of the dye to glutathione. Lidocaine pharmacokinetics were unaffected by parasitism and the only effect on ICG was an increased volume of distribution consistent with the liver hypertrophy caused by the subclinical fascioliasis.
磺溴酞钠（BSP）、利多卡因和吲哚菁绿（ICG）的药代动力学进行了测定，这些测定是在绵羊经口服150个肝片吸虫囊蚴感染后的第4、8、12、16和24周进行的。从感染后8周起，BSP的总血浆清除率显著降低，其处置发生了改变。这种变化可能与消除速率常数较低的值有关，这与该染料与谷胱甘肽的肝细胞溶质结合减少一致。利多卡因的药代动力学不受寄生虫感染的影响，对ICG的唯一影响是分布容积增加，这与亚临床肝片吸虫病引起的肝脏肥大一致。
