姜黄素对人免疫缺陷病毒 1 糖蛋白 120 V3 环诱导的大鼠神经元损伤的保护作用。
Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats.
机构信息
Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China.
Department of Orthopedics, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China.
出版信息
Neural Regen Res. 2012 Jan 25;7(3):171-5. doi: 10.3969/j.issn.1673-5374.2012.03.002.
Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury.
姜黄素改善 gp120 V3 环诱导的大鼠学习记忆障碍。本研究用 1 nM gp120 V3 环和 1 μM 姜黄素培养大鼠海马神经元 24 小时。结果表明，姜黄素抑制 gp120 V3 环诱导的线粒体膜电位下降，降低促凋亡基因 caspase-3 的 mRNA 表达，减轻海马神经元损伤。
Zotero 插件