Department of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, Fujian Province, China.
Department of Acupuncture and Tuina, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, Fujian Province, China.
Neural Regen Res. 2012 Jan 25;7(3):207-11. doi: 10.3969/j.issn.1673-5374.2012.03.009.
This study investigated the mechanism underlying electroacupuncture therapy for vascular dementia through electroacupuncture at the acupoints of Baihui (DU20), Dazhui (DU14), and bilateral Shenshu (BL23) in a rat model of vascular dementia produced by bilateral middle cerebral artery occlusion. Morris water maze test showed that electroacupuncture improved the learning ability of vascular dementia rats. Western blot assay revealed that the expression of p70 ribosomal protein S6 kinase and ribosomal protein S6 in vascular dementia rats was significantly increased after electroacupuncture, compared with the model group that was not treated with acupuncture. The average escape latency was also shortened after electroacupuncture, and escape strategies in the spatial probe test improved from edge and random searches, to linear and trending swim pathways. The experimental findings indicate that electroacupuncture improves learning and memory ability by up-regulating expression of p70 ribosomal protein S6 kinase and ribosomal protein S6 in the hippocampus of vascular dementia rats.
本研究通过电针对血管性痴呆大鼠双侧大脑中动脉闭塞模型的百会（DU20）、大椎（DU14）和双侧肾俞（BL23）穴位进行电针治疗，探讨了电针治疗血管性痴呆的机制。Morris 水迷宫试验表明，电针对血管性痴呆大鼠的学习能力有改善作用。Western blot 检测显示，电针治疗后血管性痴呆大鼠的 p70 核糖体蛋白 S6 激酶和核糖体蛋白 S6 的表达明显增加，与未接受针刺治疗的模型组相比。电针治疗后平均逃避潜伏期缩短，空间探针测试中的逃避策略从边缘和随机搜索转变为线性和趋势性游泳路径。实验结果表明，电针通过上调血管性痴呆大鼠海马 p70 核糖体蛋白 S6 激酶和核糖体蛋白 S6 的表达，改善学习和记忆能力。
