Li Guangyao, Shi Yuling, Zhang Lu, Yang Chuanghui, Wan Ting, Lv Hang, Jian Wenxuan, Li Jinghu, Li Min
Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Aging Neurosci. 2022 Aug 18;14:952181. doi: 10.3389/fnagi.2022.952181. eCollection 2022.
Acupuncture is widely used in clinical practice for the treatment of vascular diseases. However, the protocol, efficacy, and mechanism of acupuncture in animal models of vascular dementia are still controversial. Based on the above problems, we initiated this comprehensive study.
To analyze the literatures included in this study, 4 databases were searched and the SYRCLE's Risk of bias tool was employed. To perform the subgroup analysis of different acupuncture methods and the Review Manager 5.3 was applied. Meanwhile, the pairwise and network meta-analysis were conducted using Addis 1.16.8. The outcomes included escape latency, number of crossings, time spent in the target quadrant, and swimming speed.
Forty-two studies with a total of 1,486 animals were included in this meta-analysis. According to the results from subgroup analysis, GV20 + ST36 (Baihui + bilateral Zusanli) combined with 14-day manual acupuncture can obtain best improvement of the rats cognitive function among all acupuncture regimens (MD: -23.41; 95%CI: -26.66, -20.15; I = 0%; < 0.001). The heterogeneity of other acupuncture treatments was significantly higher than that of GV20 + ST36, because the treatment courses were not uniform. Pair-wise and network comparisons are highly consistent. The major results of the network meta-analysis were as follows, In comparison to the impaired group, the acupuncture group showed significantly reduced escape latency (MD: -25.87; 95%CI: -30.75, -21.12), increased number of original platform crossings (MD: 2.63; 95%CI: 1.94, 3.34) and time spent in the target quadrant (MD: 7.88; 95%CI: 4.25, 11.44). The overall results of the network meta-analysis are as follows: the normal and sham-operated groups performed the best, followed by medicine and acupuncture, while no effect was found in the impaired group treated with non-acupoint and palliative.
Acupuncture significantly improves cognitive function in rats with vascular dementia. Compared to other acupuncture plans, (GV20 + ST36, MA) and 14 -day manual acupuncture can be used to obtain better results. The main mechanism of acupuncture in the treatment of vascular dementia is reduced oxidative stress, neuronal inflammation, and apoptosis, as well as the increased synaptic plasticity and neurotransmitters.
https://inplasy.com/inplasy-2021-11-0036/, identifier: INPLASY2021110036.
针灸在血管疾病的临床治疗中应用广泛。然而，在血管性痴呆动物模型中，针灸的方案、疗效及机制仍存在争议。基于上述问题，我们开展了这项综合性研究。
为分析本研究纳入的文献，检索了4个数据库，并采用SYRCLE偏倚风险工具。为进行不同针灸方法的亚组分析，应用了Review Manager 5.3。同时，使用Addis 1.16.8进行成对和网状荟萃分析。结局指标包括逃避潜伏期、穿越次数、在目标象限停留的时间和游泳速度。
本荟萃分析纳入了42项研究，共1486只动物。根据亚组分析结果，在所有针灸方案中，百会（GV20）+双侧足三里（ST36）联合14天的手针治疗能使大鼠认知功能得到最佳改善（MD：-23.41；95%CI：-26.66，-20.15；I² = 0%；P < 0.001）。其他针灸治疗的异质性显著高于百会（GV20）+双侧足三里（ST36），因为疗程不统一。成对比较和网状比较高度一致。网状荟萃分析的主要结果如下：与损伤组相比，针灸组逃避潜伏期显著缩短（MD：-25.87；95%CI：-30.75，-21.12），原平台穿越次数增加（MD：2.63；95%CI：1.94，3.34），在目标象限停留的时间增加（MD：7.88；95%CI：4.25，11.44）。网状荟萃分析的总体结果如下：正常组和假手术组效果最佳，其次是药物组和针灸组，而在非穴位和姑息治疗的损伤组中未发现效果。
针灸能显著改善血管性痴呆大鼠的认知功能。与其他针灸方案相比，（百会（GV20）+双侧足三里（ST36），手针）和14天的手针治疗可获得更好的效果。针灸治疗血管性痴呆的主要机制是减轻氧化应激、神经元炎症和细胞凋亡，以及增加突触可塑性和神经递质。
https://inplasy.com/inplasy-2021-11-0036/，标识符：INPLASY2021110036。
