Ghanizadeh Ahmad, Berk Michael
Research Center for Psychiatry and Behavioral Sciences, Shiraz University of Medical Sciences, Shiraz, Iran ; Department of Psychiatry, Shiraz University of Medical Sciences, School of Medicine, Shiraz, Iran ; Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Professor of Psychiatry, School of Medicine, Deakin University, Melbourne, Australia ; Professorial Research Fellow, The Florey Institute of Neuroscience and Mental Health, Orygen Research Centre and the Department of Psychiatry, University of Melbourne, Melbourne, Australia.
Iran J Child Neurol. 2015 Winter;9(1):99-102.
Autism is a disorder of unknown etiology. There are few FDA approved medications for treating autism. Co-occurring autism and epilepsy is common, and glutamate antagonists improve some symptoms of autism. Ceftriaxone, a beta-lactam antibiotic, increases the expression of the glutamate transporter 1 which decreases extracellular glutamate levels. It is hypothesized that modulating astrocyte glutamate transporter expression by ceftriaxone or cefixime might improve some symptoms of autism. This case report of a child with autism and epilepsy suggests a decrease in seizures after taking cefixime.
自闭症是一种病因不明的疾病。美国食品药品监督管理局（FDA）批准用于治疗自闭症的药物很少。自闭症与癫痫共病很常见，谷氨酸拮抗剂可改善自闭症的一些症状。头孢曲松，一种β-内酰胺类抗生素，可增加谷氨酸转运体1的表达，从而降低细胞外谷氨酸水平。据推测，通过头孢曲松或头孢克肟调节星形胶质细胞谷氨酸转运体的表达可能会改善自闭症的一些症状。这例自闭症和癫痫患儿的病例报告表明服用头孢克肟后癫痫发作减少。
