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体育锻炼和间歇性服用乳果糖可能通过产氢改善自闭症症状。

Physical exercise and intermittent administration of lactulose may improve autism symptoms through hydrogen production.

作者信息

Ghanizadeh Ahmad

机构信息

Research Center for Psychiatry and Behavioral Sciences, Department of Psychiatry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

Med Gas Res. 2012 Jul 30;2(1):19. doi: 10.1186/2045-9912-2-19.

DOI:10.1186/2045-9912-2-19
PMID:22846252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3464164/
Abstract

Autism is neuro-developmental disorder. Oxidative stress is enhanced in some children with autism. Hydrogen is a gas with anti-oxidative effects suggested for treating or prevention of some medical problems. It is hypothesized that lactulose or hydrogen water may provide hydrogen to reduce oxidative stress in autism.

摘要

自闭症是一种神经发育障碍。一些自闭症儿童的氧化应激增强。氢气是一种具有抗氧化作用的气体，被认为可用于治疗或预防某些医学问题。据推测，乳果糖或氢水可能会提供氢气以减轻自闭症中的氧化应激。

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本文引用的文献

1
Hydrogen as a novel hypothesized emerging treatment for oxidative stress in autism.氢气作为一种新的假设性新兴疗法用于治疗自闭症中的氧化应激。
Eur Rev Med Pharmacol Sci. 2012 Sep;16(9):1313-4.
2
Glutathione-related factors and oxidative stress in autism, a review.自闭症中与谷胱甘肽相关的因素和氧化应激：综述
Curr Med Chem. 2012;19(23):4000-5. doi: 10.2174/092986712802002572.
3
Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats.处理氢分子可减轻模拟微重力引起的大鼠氧化应激和骨丢失。
Osteoporos Int. 2013 Mar;24(3):969-78. doi: 10.1007/s00198-012-2028-4. Epub 2012 May 31.
4
Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats.饮用氢水和间歇性暴露于氢气，而非乳果糖或持续性暴露于氢气，可预防6-羟基多巴胺诱导的大鼠帕金森病。
Med Gas Res. 2012 May 20;2(1):15. doi: 10.1186/2045-9912-2-15.
5
Hyperbaric oxygen therapy for treatment of children with autism: a systematic review of randomized trials.高压氧疗法治疗儿童自闭症：随机试验的系统评价
Med Gas Res. 2012 May 11;2:13. doi: 10.1186/2045-9912-2-13.
6
Targeting Mitochondria by Olesoxime or Complement 1q Binding Protein as a Novel Management for Autism: A Hypothesis.通过奥来昔明或补体1q结合蛋白靶向线粒体作为自闭症的一种新型治疗方法：一项假说
Mol Syndromol. 2011 Dec;2(1):50-52. doi: 10.1159/000332202. Epub 2011 Oct 12.
7
Gastrointestinal dysfunction in autism: parental report, clinical evaluation, and associated factors.自闭症患者的胃肠道功能障碍：家长报告、临床评估及相关因素。
Autism Res. 2012 Apr;5(2):101-8. doi: 10.1002/aur.237.
8
Global prevalence of autism and other pervasive developmental disorders.全球自闭症和其他普遍性发育障碍的患病率。
Autism Res. 2012 Jun;5(3):160-79. doi: 10.1002/aur.239. Epub 2012 Apr 11.
9
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Br J Community Nurs. 2011 Dec;16(12):584, 586, 588-90. doi: 10.12968/bjcn.2011.16.12.584.
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Malondialdehyde, Bcl-2, superoxide dismutase and glutathione peroxidase may mediate the association of sonic hedgehog protein and oxidative stress in autism.丙二醛、Bcl-2、超氧化物歧化酶和谷胱甘肽过氧化物酶可能介导了自闭症中 sonic hedgehog 蛋白和氧化应激的关联。
Neurochem Res. 2012 Apr;37(4):899-901. doi: 10.1007/s11064-011-0667-z. Epub 2011 Dec 6.