3-甲基吲哚诱导的山羊肺损伤中表面活性剂功能受损。

Impaired surfactant function in 3-methylindole-induced lung injury in goats.

Kirkland J B, Bray T M

Department of Nutritional Sciences, College of Biological Science, University of Guelph, Ontario, Canada.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1989;94(2):591-3. doi: 10.1016/0742-8413(89)90118-7.

Abstract

This study was designed to monitor the changes in surfactant quantity and function in the 72 hr following 3-methylindole (3MI) infusion in goats. 2. 3MI, at 35 mg/kg body wt, caused an increase in surfactant phospholipid isolated from lamellar bodies and lavage fluid. 3. The function of surfactant isolated from lavage fluid was tested using the pulsating bubble surfactometer. The results indicated a serious impairment in the ability to lower surface tension in vitro. 4. Results suggested 3MI caused an impaired surfactant function rather than surfactant synthesis in response to epithelial damage.

摘要

本研究旨在监测山羊输注3-甲基吲哚（3MI）后72小时内表面活性剂数量和功能的变化。2. 以35毫克/千克体重的剂量注射3MI，导致从板层小体和灌洗液中分离出的表面活性剂磷脂增加。3. 使用脉动气泡表面张力测定仪测试从灌洗液中分离出的表面活性剂的功能。结果表明其在体外降低表面张力的能力严重受损。4. 结果表明，3MI导致表面活性剂功能受损，而非因上皮损伤引起表面活性剂合成受损。