Delise P, D'Este D, Bonso A, Allibardi P, Raviele A, Di Pede F, Piccolo E
Divisione di Cardiologia, Ospedale di Mestre, Venezia.
G Ital Cardiol. 1989 Dec;19(12):1094-104.
Transesophageal electrophysiologic study has recently been proposed for the evaluation of supraventricular arrhythmias. In this report we present 13 cases, with palpitations occurring only during effort, due to a suspected supraventricular tachycardia, in which the usefulness of the transesophageal electrophysiologic study performed during stress test was evaluated. Of these 13 patients, nine were male and four were female, mean age was 29 yrs. Twelve cases had no heart disease, one had a moderate mitral valve insufficiency. Nine cases had a normal ECG, four had a WPW pattern. In 9/13 cases no significant arrhythmia was ever documented, in 1/13 ventricular premature beats were present in the basal ECG, in 1/13 a atrial fibrillation and in 2/13 a supraventricular reciprocating tachycardia was recorded. In all cases a maximal exercise test and a 24-hour Holter monitoring were performed. In all pts a transesophageal electrophysiologic study was performed both at rest and during extra-stimuli and incremental atrial pacing. The end point of transesophageal study was the induction of a sustained (greater than 30") supraventricular tachycardia. RESULTS. Maximal exercise test was negative in 11/13 cases; it showed ventricular premature beats in one case and initiated a supraventricular tachycardia in one. The 24 hour Holter monitoring was negative in 12/13 cases while it showed frequent ventricular premature beats in one. Resting transesophageal electrophysiologic study revealed dual A-V nodal pathways in six pts: in one of them a junctional re-entry was induced; in two a single echo beat was observed, while in three no reentry was observed. In three cases a supraventricular tachycardia was induced which was sustained in one and unsustained (7" and 24") in two cases. In 4 cases transesophageal electrophysiologic study gave no information. Transesophageal stimulation during exercise induced a greater than 30" reciprocating tachycardia in all patients, at work loads of 30-180 watts. Six pts had an intranodal tachycardia (V-A less than 70 msec) a further six pts had a atrioventricular tachycardia involving a Kent bundle (V-A greater than or equal to 70 msec), which was concealed in two, and one had a atrial tachycardia. In four cases (3 with intranodal and 1 with atrioventricular tachycardia), exercise transesophageal study was repeated after chronic therapy with betablockers (sotalol 240 mg/die or metoprolol 200 mg/die). In all cases, after therapy, the induced tachycardia had a longer cycle and in two cases it was induced at a higher work load. In a further two cases flecainide (200 mg/die) was tested. In one case (with atrial tachycardia), the arrhythmia was no longer inducible after therapy, in another case (with intranodal tachycardia) the drug had no effect. CONCLUSIONS. In patients with paroxysmal supraventricular tachyarrhythmias occurring during effort the basal ECG is normal or shows a WPW pattern. The maximal exercise test and 24 hour Holter monitoring give no information in over 90% of cases.(ABSTRACT TRUNCATED AT 400 WORDS)
经食管电生理研究最近被用于评估室上性心律失常。在本报告中,我们呈现了13例仅在运动时出现心悸的患者,怀疑为室上性心动过速,对其在运动试验期间进行经食管电生理研究的实用性进行了评估。这13例患者中,9例为男性,4例为女性,平均年龄29岁。12例无心脏病,1例有中度二尖瓣关闭不全。9例心电图正常,4例有预激综合征图形。13例中有9例未记录到明显心律失常,13例中有1例基础心电图有室性早搏,13例中有1例房颤,13例中有2例记录到室上性折返性心动过速。所有病例均进行了最大运动试验和24小时动态心电图监测。所有患者均在静息状态及额外刺激和递增心房起搏时进行了经食管电生理研究。经食管研究的终点是诱发持续(大于30秒)的室上性心动过速。结果。13例中有11例最大运动试验阴性;1例显示室性早搏,1例诱发了室上性心动过速。13例中有12例24小时动态心电图监测阴性,1例显示频发室性早搏。静息经食管电生理研究显示6例患者有双房室结径路:其中1例诱发了交界性折返;2例观察到单个回波,3例未观察到折返。3例诱发了室上性心动过速,1例持续,2例不持续(7秒和24秒)。4例经食管电生理研究未提供信息。运动期间经食管刺激在所有患者中,在30 - 180瓦的工作负荷下诱发了大于30秒的折返性心动过速。6例患者有结内心动过速(室房传导小于70毫秒),另外6例患者有涉及肯特束的房室性心动过速(室房传导大于或等于70毫秒),其中2例为隐匿性,1例为房性心动过速。4例患者(3例结内心动过速和1例房室性心动过速)在使用β受体阻滞剂(索他洛尔240毫克/天或美托洛尔200毫克/天)长期治疗后重复进行运动经食管研究。所有病例治疗后,诱发的心动过速周期更长,2例在更高的工作负荷下诱发。另外2例患者测试了氟卡尼(200毫克/天)。1例患者(房性心动过速)治疗后不再能诱发心律失常,另1例患者(结内心动过速)药物无效。结论。在运动时发生阵发性室上性快速心律失常的患者中,基础心电图正常或显示预激综合征图形。最大运动试验和24小时动态心电图监测在超过90%的病例中未提供信息。(摘要截短至400字)