Gerschenfeld H M, Paupardin-Tritsch D, Hammond C, Harris-Warrïck R
Laboratoire de Neurobiologie, Ecole Normale Supérieure, Paris, France.
Cell Biol Int Rep. 1989 Dec;13(12):1141-54. doi: 10.1016/0309-1651(89)90028-3.
This paper reviews our work on the modulation of voltage-dependent Ca currents in identified snail neurons. Ca currents of snail neurones are enhanced or decreased by neurotransmitters. Serotonin and acetylcholine enhance the Ca current of identified neurons, the effect of serotonin being mediated by cGMP and cGMP-dependent protein kinase. Cholecystokinin (CCK8) and dopamine both decrease the Ca current of identified neurons. The effect of CCK8 is irreversible and involves the activation of protein kinase C. The dopamine-induced decrease in Ca current is reversible and involves an alpha 40 subunit of a snail G protein immunologically and functionally related to alpha o of mammalian brain.
本文回顾了我们在已鉴定的蜗牛神经元中对电压依赖性钙电流调节方面的工作。蜗牛神经元的钙电流可被神经递质增强或减弱。5-羟色胺和乙酰胆碱增强已鉴定神经元的钙电流，5-羟色胺的作用由环鸟苷酸（cGMP）和cGMP依赖性蛋白激酶介导。胆囊收缩素（CCK8）和多巴胺均降低已鉴定神经元的钙电流。CCK8的作用是不可逆的，且涉及蛋白激酶C的激活。多巴胺引起的钙电流降低是可逆的，并且在免疫学和功能上涉及一种与哺乳动物脑αo相关的蜗牛G蛋白的α40亚基。
