Deutsch Gary B, Kirchoff Daniel D, Faries Mark B
Melanoma Research Program, John Wayne Cancer Institute, Providence St. John's Hospital, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA.
Melanoma Research Program, John Wayne Cancer Institute, Providence St. John's Hospital, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA.
Surg Oncol Clin N Am. 2015 Apr;24(2):279-98. doi: 10.1016/j.soc.2014.12.006. Epub 2015 Jan 27.
Metastatic melanoma has an unpredictable natural history but a predictably high mortality. Despite recent advances in systemic therapy, many patients do not respond, or develop resistance to drug therapy. Surgery has consistently shown good outcomes in appropriately selected patients. It is likely to be even more successful in the era of more effective medical treatment. Surgery should remain a strongly considered option for metastatic melanoma.
转移性黑色素瘤的自然病程不可预测，但死亡率却居高不下。尽管近期全身治疗取得了进展，但许多患者对药物治疗无反应或产生耐药性。手术在经过适当选择的患者中一直显示出良好的效果。在更有效的药物治疗时代，手术可能会更加成功。对于转移性黑色素瘤，手术仍应是一个值得重点考虑的选择。
