Larner A J
Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom
J Geriatr Psychiatry Neurol. 2015 Sep;28(3):198-202. doi: 10.1177/0891988715573536. Epub 2015 Mar 12.
The diagnostic accuracy of the AD8 informant questionnaire for cognitive impairment was assessed in patients referred to a dedicated memory clinic. This pragmatic prospective study of consecutive referrals attending with an informant who completed AD8 (n = 212) lasted 12 months. Diagnosis used standard clinical diagnostic criteria for dementia and mild cognitive impairment as reference standard (prevalence of cognitive impairment = 0.62). The AD8 proved acceptable to informants, was quick, and easy to use. Using the cutoff of ≥2/8, AD8 was highly sensitive (0.97) for diagnosis of cognitive impairment but specificity was poor (0.17). Combining AD8 with either the Mini-Mental State Examination or the Six-Item Cognitive Impairment Test showed little additional diagnostic benefit. In conclusion, AD8 is very sensitive for cognitive impairment in a memory clinic but specificity may be inadequate.
在被转诊至专门记忆门诊的患者中，评估了AD8知情者问卷对认知障碍的诊断准确性。这项针对连续转诊且有完成AD8问卷的知情者参与的务实前瞻性研究（n = 212）持续了12个月。诊断采用痴呆和轻度认知障碍的标准临床诊断标准作为参考标准（认知障碍患病率 = 0.62）。结果表明，AD8问卷对知情者来说是可接受的，快速且易于使用。采用≥2/8的临界值时，AD8对认知障碍诊断的敏感性很高（0.97），但特异性较差（0.17）。将AD8与简易精神状态检查表或六项认知障碍测试相结合，几乎没有额外的诊断益处。总之，AD8对记忆门诊中的认知障碍非常敏感，但特异性可能不足。
