Parodi Alessia, Kalli Francesca, Svahn Johanna, Stroppiana Giorgia, De Rocco Daniela, Terranova Paola, Dufour Carlo, Fenoglio Daniela, Cappelli Enrico
Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy.
Hematology Unit, Istituto Giannina Gaslini, 16148 Genova, Italy.
Cytokine. 2015 May;73(1):203-7. doi: 10.1016/j.cyto.2015.02.016. Epub 2015 Mar 10.
Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure and cancer predisposition. Several studies show alterations of the immunological status of FA patients including defects in peripheral blood lymphocyte subsets, serum immunoglobulin levels, and inflammatory cytokines. However scanty information is available on the response of FA cells to specific infectious antigens. In this work we examined the response of FA cells to different immunological stimuli and found a defective response of IL-1β, TNF-α and IL-17 to Candida albicans stimulation thus pointing to a potentially impaired response to fungal infections of FA patients.
范可尼贫血（FA）是一种遗传性疾病，其特征为骨髓衰竭和癌症易感性。多项研究表明，FA患者的免疫状态存在改变，包括外周血淋巴细胞亚群、血清免疫球蛋白水平和炎性细胞因子的缺陷。然而，关于FA细胞对特定感染性抗原的反应的信息却很少。在这项研究中，我们检测了FA细胞对不同免疫刺激的反应，发现IL-1β、TNF-α和IL-17对白色念珠菌刺激的反应存在缺陷，从而表明FA患者对真菌感染的反应可能受损。
