Bi Hong-Sheng, Liu Zheng-Feng, Cui Yan
Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China; Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
J Chin Med Assoc. 2015 May;78(5):276-82. doi: 10.1016/j.jcma.2015.01.002. Epub 2015 Mar 11.
Experimental autoimmune uveitis, a well-established model for human uveitis, is similar to human uveitis in many pathological features. Studies concerning the mechanisms of experimental autoimmune uveitis would cast a light on the pathogenesis of human uveitis as well as the search for more effective therapeutic agents. The cellular components of innate immunity include natural killer cells, gamma delta T lymphocytes, antigen-presenting dendritic cells, phagocytic macrophages, and granulocytes. It is believed that T cells are central in the generation of human uveitis. It has already become clear that CD4(+) effecter cells that predominantly produce interleukin-17 (the so-called Th17 cells) may play an important role in uveitis. In addition, the occurrence and recurrence of uveitis depends on a complex interplay between the elements of innate and adaptive immunity.
实验性自身免疫性葡萄膜炎是一种成熟的人类葡萄膜炎模型，在许多病理特征上与人类葡萄膜炎相似。关于实验性自身免疫性葡萄膜炎发病机制的研究将有助于揭示人类葡萄膜炎的发病机制，并有助于寻找更有效的治疗药物。固有免疫的细胞成分包括自然杀伤细胞、γδT淋巴细胞、抗原呈递树突状细胞、吞噬性巨噬细胞和粒细胞。人们认为T细胞在人类葡萄膜炎的发生中起核心作用。已经明确的是，主要产生白细胞介素-17的CD4(+)效应细胞（即所谓的Th17细胞）可能在葡萄膜炎中起重要作用。此外，葡萄膜炎的发生和复发取决于固有免疫和适应性免疫成分之间复杂的相互作用。
