Racing to the flatline: heart rate and β-adrenergic stimulation quicken the pace.
作者信息
Kay Matthew, Kuzmiak-Glancy Sarah, Rogers Jack
机构信息
Department of Biomedical Engineering, The George Washington University, Washington, District of Columbia; and
Department of Biomedical Engineering, The George Washington University, Washington, District of Columbia; and.
出版信息
Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H977-9. doi: 10.1152/ajpheart.00154.2015. Epub 2015 Mar 13.
Abstract
摘要
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本文引用的文献
1
β-Adrenergic stimulation and rapid pacing mutually promote heterogeneous electrical failure and ventricular fibrillation in the globally ischemic heart.β-肾上腺素能刺激与快速起搏相互促进整体缺血心脏中的异质性电衰竭和心室颤动。
Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H1155-70. doi: 10.1152/ajpheart.00768.2014. Epub 2015 Feb 20.
2
Resting heart rate: risk indicator and emerging risk factor in cardiovascular disease.静息心率：心血管疾病的风险指标和新兴危险因素。
Am J Med. 2015 Mar;128(3):219-28. doi: 10.1016/j.amjmed.2014.09.016. Epub 2014 Oct 15.
3
The importance of Purkinje activation in long duration ventricular fibrillation.浦肯野纤维激活在长时间心室颤动中的重要性。
J Am Heart Assoc. 2014 Feb 28;3(1):e000495. doi: 10.1161/JAHA.113.000495.
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NADH changes during hypoxia, ischemia, and increased work differ between isolated heart preparations.在缺氧、缺血和工作增加期间，NADH 的变化在分离的心脏制剂之间有所不同。
Am J Physiol Heart Circ Physiol. 2014 Feb 15;306(4):H529-37. doi: 10.1152/ajpheart.00696.2013. Epub 2013 Dec 13.
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Ivabradine but not propranolol delays the time to onset of ischaemia-induced ventricular fibrillation by preserving myocardial metabolic energy status.伊伐布雷定可通过维持心肌代谢能量状态而延迟缺血诱导的室颤发生时间，而普萘洛尔则没有这种作用。
Resuscitation. 2013 Mar;84(3):384-90. doi: 10.1016/j.resuscitation.2012.07.041. Epub 2012 Aug 31.
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Implantable cardioverter-defibrillators have reduced the incidence of resuscitation for out-of-hospital cardiac arrest caused by lethal arrhythmias.植入式心脏复律除颤器降低了由致命性心律失常引起的院外心脏骤停患者的复苏发生率。
Circulation. 2012 Aug 14;126(7):815-21. doi: 10.1161/CIRCULATIONAHA.111.089425. Epub 2012 Aug 6.
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Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia.局部β肾上腺素能刺激克服源-汇不匹配以产生局灶性心律失常。
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