Suppr超能文献

节奏性听觉提示能否改善帕金森病中与语言相关的缺陷?

Can rhythmic auditory cuing remediate language-related deficits in Parkinson's disease?

作者信息

Kotz Sonja A, Gunter Thomas C

机构信息

School of Psychological Sciences, University of Manchester, Manchester, United Kingdom; Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

出版信息

Ann N Y Acad Sci. 2015 Mar;1337:62-8. doi: 10.1111/nyas.12657.

Abstract

Neurodegenerative changes of the basal ganglia in idiopathic Parkinson's disease (IPD) lead to motor deficits as well as general cognitive decline. Given these impairments, the question arises as to whether motor and nonmotor deficits can be ameliorated similarly. We reason that a domain-general sensorimotor circuit involved in temporal processing may support the remediation of such deficits. Following findings that auditory cuing benefits gait kinematics, we explored whether reported language-processing deficits in IPD can also be remediated via auditory cuing. During continuous EEG measurement, an individual diagnosed with IPD heard two types of temporally predictable but metrically different auditory beat-based cues: a march, which metrically aligned with the speech accent structure, a waltz that did not metrically align, or no cue before listening to naturally spoken sentences that were either grammatically well formed or were semantically or syntactically incorrect. Results confirmed that only the cuing with a march led to improved computation of syntactic and semantic information. We infer that a marching rhythm may lead to a stronger engagement of the cerebello-thalamo-cortical circuit that compensates dysfunctional striato-cortical timing. Reinforcing temporal realignment, in turn, may lead to the timely processing of linguistic information embedded in the temporally variable speech signal.

摘要

特发性帕金森病(IPD)中基底神经节的神经退行性变化会导致运动功能障碍以及整体认知能力下降。鉴于这些损伤,就产生了一个问题,即运动和非运动缺陷是否能以类似的方式得到改善。我们推断,一个参与时间处理的通用感觉运动回路可能支持此类缺陷的修复。基于听觉提示对步态运动学有好处这一发现,我们探究了IPD中报告的语言处理缺陷是否也能通过听觉提示得到修复。在连续脑电图测量过程中,一名被诊断为IPD的个体听到两种基于听觉节拍的、时间上可预测但节拍不同的提示:一种是与语音重音结构节拍一致的进行曲,一种是节拍不一致的华尔兹,或者在听语法正确、语义或句法不正确的自然口语句子之前不给予提示。结果证实,只有进行曲提示能改善句法和语义信息的处理。我们推断,进行曲节奏可能会使小脑 - 丘脑 - 皮质回路更强地参与其中,从而补偿功能失调的纹状体 - 皮质时间安排。反过来,加强时间对齐可能会导致及时处理嵌入在时间可变语音信号中的语言信息。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验