Healy Genevieve N, Winkler Elisabeth A H, Brakenridge Charlotte L, Reeves Marina M, Eakin Elizabeth G
The University of Queensland, School of Public Health, Brisbane, Australia; Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia; Curtin University, School of Physiotherapy, Perth, Western Australia, Australia.
The University of Queensland, School of Public Health, Brisbane, Australia.
PLoS One. 2015 Mar 16;10(3):e0119140. doi: 10.1371/journal.pone.0119140. eCollection 2015.
To examine the associations of sedentary time and physical activity with biomarkers of cardiometabolic health, including the potential collective impact of shifting mean time use from less- to more-active behaviours (cross-sectionally, using isotemporal substitution), in adults with type 2 diabetes.
Participants with overweight/obese body mass index (BMI; ≥25 kg/m2) (n = 279; 158 men, mean [SD] age = 58.2 [8.6] years) wore Actigraph GT1M accelerometers (waking hours; seven days) to assess moderate- to vigorous-intensity physical activity (MVPA), light-intensity activity, and sedentary time (segregated into non-prolonged [accumulated in bouts <30min] and prolonged [accumulated in bouts ≥30 min]). Cross-sectional associations with waist circumference, BMI, fasting blood (HbA1c, glucose, triacylglycerols, high-density lipoprotein cholesterol), and blood pressure of these activity variables (30 min/day increments) were examined adjusted for confounders and wear then, if significant, examined using isotemporal substitution modelling.
Waist circumference and BMI were significantly (p<0.05) associated with more prolonged sedentary time and less light-intensity activity. Light intensity activity was also significantly associated with lower fasting plasma glucose (relative rate: 0.98, 95% CI: 0.97, 1.00; p<0.05). No biomarker was significantly associated with non-prolonged sedentary time or MVPA. Lower mean prolonged sedentary time (-30 min/day) with higher mean light intensity time (+30 min/day) was significantly associated with lower waist circumference (β = -0.77, 95% CI: -1.33, -0.22 cm). Lower mean prolonged sedentary time (-30 min/day) with either 30 min/day higher mean non-prolonged sedentary time (β = -0.35, 95%CI: -0.70, -0.01 kg/m2) or light-intensity time (β = -0.36, -0.61, -0.11 kg/m2) was associated with significantly lower average BMI.
Significantly improved mean levels of waist circumference and BMI were observed when shifting time from prolonged sedentary to non-prolonged sedentary or light-intensity activity (cross-sectionally). Lifestyle interventions in overweight/obese adults with type 2 diabetes might consider targeting shifts in these non-MVPA activities to more rigorously evaluate their potential cardiometabolic benefit in this population.
研究久坐时间和身体活动与成人2型糖尿病患者心脏代谢健康生物标志物之间的关联，包括将平均时间使用从较少活动行为转变为较多活动行为的潜在综合影响（横断面研究，采用等时替代法）。
体重指数（BMI）超重/肥胖（≥25kg/m²）的参与者（n = 279；158名男性，平均[标准差]年龄 = 58.2[8.6]岁）佩戴Actigraph GT1M加速度计（清醒时间；七天），以评估中等至剧烈强度身体活动（MVPA）、轻度强度活动和久坐时间（分为非长时间[以<30分钟的时间段累计]和长时间[以≥30分钟的时间段累计]）。在调整混杂因素和佩戴情况后，研究这些活动变量（每天增加30分钟）与腰围、BMI、空腹血糖（糖化血红蛋白、葡萄糖、三酰甘油、高密度脂蛋白胆固醇）和血压的横断面关联，若有显著性，则使用等时替代模型进行研究。
腰围和BMI与更长时间的久坐和更少轻度强度活动显著相关（p<0.05）。轻度强度活动也与较低的空腹血糖显著相关（相对率：0.98，95%置信区间：0.97，1.00；p<0.05）。没有生物标志物与非长时间久坐或MVPA显著相关。平均长时间久坐时间降低（-30分钟/天）且平均轻度强度时间增加（+30分钟/天）与较低的腰围显著相关（β = -0.77，95%置信区间：-1.33，-0.22厘米）。平均长时间久坐时间降低（-30分钟/天），同时平均非长时间久坐时间增加30分钟/天（β = -0.35，95%置信区间：-0.70，-0.01kg/m²）或轻度强度时间增加30分钟/天（β = -0.36，-0.61，-0.11kg/m²）与显著降低的平均BMI相关。
当时间从长时间久坐转变为非长时间久坐或轻度强度活动时（横断面研究），观察到腰围和BMI的平均水平有显著改善。对超重/肥胖的2型糖尿病成人进行生活方式干预时，可能应考虑针对这些非MVPA活动的转变，以更严格地评估其在该人群中的潜在心脏代谢益处。
