Dehdari Tahereh, Shahraki-Sanavi Fariba, Nasiri Amir, Nouri Roghayeh, Moghaddam Alireza A, Mohammadi Mahdi
Department of Health Promotion and Education School of Public Health, Iran University of Medical Sciences Tehran Iran.
Health Promotion Research Center Zahedan University of Medical Sciences Zahedan Iran.
Health Sci Rep. 2025 Apr 21;8(4):e70658. doi: 10.1002/hsr2.70658. eCollection 2025 Apr.
Given the influence of lifestyle on type 2 diabetes mellitus (T2DM), the present study aimed to investigate the association between physical activity (PA) intensity and T2DM among sedentary and active participants in the Zahedan Adult Cohort Study (ZACS), Iran.
This cross-sectional study was conducted as part of the population-based Persian Prospective Epidemiological Research Studies in Iran (Persian Cohort). The baseline data from the ZACS collected between 2015 and 2019 were utilized. A total of 10,004 adults aged 35-70 years were included in the analysis. Data were gathered through self-reported questionnaires covering general information, socioeconomic status, sleep status, medical history, and PA. Anthropometric measurements and biochemical parameters were obtained from participants after a 12-h fasting period. The data were analyzed using descriptive statistics, independent-sample -test, chi-square, and logistic regression tests in SPSS22.
The study found that the majority of the 10,004 adult participants (81.2%) were sedentary, while only 18.8% were classified as active. Sedentary participants exhibited significantly higher mean values for various health markers, including age, education, sleep duration, weight, body mass index (BMI), and blood lipid levels, as well as higher prevalence of hypertension, cardiac conditions, and stroke compared to active participants. Additionally, 21.7% of the participants had T2DM, which was associated with older age, longer sleep duration, higher weight and BMI, and abnormal waist circumference. The prevalence of diabetes increased with higher BMI, from 4.8% in underweight to 27.1% in obese participants, and was 77% in sedentary individuals compared to 16% in active individuals. Even after adjusting for demographic factors (OR = 0.65, < 0.001), lipid levels (odds ratio [OR] = 0.68, = 0.001), sleep status (OR = 0.72, = 0.001), and family history (OR = 0.66, = 0.001), active individuals were found to have a significantly lower likelihood of being diabetic compared to their sedentary counterparts.
The findings revealed a clear association between sedentary lifestyles and an increased risk of T2DM. Physical inactivity was correlated with adverse health markers and an elevated incidence of T2DM, which was mitigated by an active lifestyle. These results underscore the importance of public health initiatives to promote PA as a critical strategy for diabetes prevention.
鉴于生活方式对2型糖尿病（T2DM）的影响，本研究旨在调查伊朗扎黑丹成人队列研究（ZACS）中久坐不动和活跃参与者的身体活动（PA）强度与T2DM之间的关联。
这项横断面研究是基于伊朗人群的波斯前瞻性流行病学研究（波斯队列）的一部分。利用了2015年至2019年期间收集的ZACS基线数据。共有10004名年龄在35 - 70岁的成年人纳入分析。通过自我报告问卷收集数据，内容涵盖一般信息、社会经济状况、睡眠状况、病史和身体活动情况。在禁食12小时后从参与者处获取人体测量数据和生化参数。在SPSS22中使用描述性统计、独立样本t检验、卡方检验和逻辑回归检验对数据进行分析。
研究发现，10004名成年参与者中的大多数（81.2%）久坐不动，而只有18.8%被归类为活跃。与活跃参与者相比，久坐参与者在各种健康指标上的平均值显著更高，包括年龄、教育程度、睡眠时间、体重、体重指数（BMI）和血脂水平，以及高血压、心脏疾病和中风的患病率更高。此外，21.7%的参与者患有T2DM，这与年龄较大、睡眠时间较长、体重和BMI较高以及腰围异常有关。糖尿病患病率随BMI升高而增加，从体重过轻人群中的4.8%到肥胖参与者中的27.1%，久坐个体中的患病率为77%，而活跃个体中的患病率为16%。即使在调整了人口统计学因素（比值比[OR]=0.65，P<0.001）、血脂水平（OR = 0.68，P = 0.001）、睡眠状况（OR = 0.72，P = 0.001）和家族病史（OR = 0.66，P = 0.001）后，仍发现活跃个体患糖尿病的可能性明显低于久坐的同龄人。
研究结果揭示了久坐生活方式与T2DM风险增加之间存在明显关联。身体不活动与不良健康指标以及T2DM发病率升高相关，而积极的生活方式可减轻这种情况。这些结果强调了公共卫生举措将促进身体活动作为预防糖尿病关键策略的重要性。
