Angioni Stefano, Nappi Luigi, Pontis Alessandro, Sedda Federica, Luisi Stefano, Mais Valerio, Melis Gian Benedetto
Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari , Monserrato , Italy .
Gynecol Endocrinol. 2015 May;31(5):406-8. doi: 10.3109/09513590.2015.1006617. Epub 2015 Mar 17.
Deep endometriosis involvement of the bladder is uncommon but it is symptomatic in most of the cases. Although laparoscopic excision is very effective, some patients with no pregnancy desire require a medical approach. We performed a pilot study on the effect of a new progestin dienogest on bladder endometriosis. Six patients were treated for 12 months with dienogest 2 mg/daily. Pain, urinary symptoms, quality of life, nodule volume and side effects were recorded. During treatment, symptoms improved very quickly and the nodules exhibit a remarkable reduction in size. Dienogest may be an alternative approach to bladder endometriosis.
膀胱深部子宫内膜异位症并不常见，但大多数病例有症状。尽管腹腔镜切除非常有效，但一些无生育意愿的患者需要药物治疗。我们对一种新型孕激素地诺孕素治疗膀胱子宫内膜异位症的效果进行了一项初步研究。6例患者接受地诺孕素2mg/日治疗12个月。记录疼痛、泌尿系统症状、生活质量、结节体积和副作用。治疗期间，症状很快改善，结节大小显著缩小。地诺孕素可能是治疗膀胱子宫内膜异位症的一种替代方法。
