Gobbi P G, Gendarini A, Crema A, Cavalli C, Attardo-Parrinello G, Federico M, Di Prisco U, Ascari E
Cancer. 1985 Jan 15;55(2):389-93. doi: 10.1002/1097-0142(19850115)55:2<389::aid-cncr2820550216>3.0.co;2-f.
Serum albumin levels were measured by electrophoresis in 552 evaluable patients with Hodgkin's disease. Determinations were made on all patients at onset, on 224 after induction therapy and on 78 in relapse after remissions of variable length. At onset a discrete hypoalbuminemia was evident, inversely related to stage and more marked in symptomatic cases and elder patients. Little or no differences in albumin levels were found with relation to histologic subtypes, sex and presence of weight loss or hepatic damage. Posttherapeutic normalization of serum albumin occurred only after achievement of complete remission and failed after partial remission, while a new clear decrease became evident in relapse. On the basis of 799 albumin measurements during active disease and in remission, the albumin/alpha 2-globulin ratio demonstrated a clear and useful clinical advantage over either albumin or alpha 2-globulin fractions alone as indicator of active disease and relapse. If defective synthesis is the most accepted mechanism for hypoalbuminemia in Hodgkin's disease, these results suggest a casual factor somehow related to the tumoral mass.
采用电泳法对552例可评估的霍奇金病患者测定血清白蛋白水平。对所有患者在发病时进行测定，224例患者在诱导治疗后进行测定，78例患者在不同长度缓解期后的复发时进行测定。发病时可见明显的低白蛋白血症，与分期呈负相关，在有症状的病例和老年患者中更明显。在组织学亚型、性别以及是否存在体重减轻或肝损伤方面，白蛋白水平几乎没有差异。血清白蛋白的治疗后正常化仅在完全缓解后出现，部分缓解后则未出现，而在复发时又出现明显的新的下降。基于799次在疾病活动期和缓解期的白蛋白测量，白蛋白/α2球蛋白比值作为疾病活动和复发的指标，相较于单独的白蛋白或α2球蛋白组分，显示出明显且有用的临床优势。如果合成缺陷是霍奇金病中低白蛋白血症最被认可的机制，那么这些结果提示存在某种与肿瘤块相关的偶然因素。
