Pasquali Paola, Freites-Martinez Azael, Hernandez Carmen, Valero Lugo Jesús, Fortuño Ángeles
Dermatology Department, Pius Hospital de Valls.
Dermatol Online J. 2014 Dec 14;21(3):13030/qt2qk2r5xd.
Cutaneous leiomyosarcomas are uncommon malignant tumors of smooth muscle. We report herein two cases of cutaneous leiomyosarcoma, one of dermal and other of subcutaneous vascular origin, confirmed by histology and immunohistochemistry. Both cases were treated with wide surgical excision, one with local recurrence. No metastases were detected at follow-up. Leiomyosarcomas should be considered in lesions with histologic features of spindle cell malignancy. It is necessary in most of the cases a histological differentiation with specific immunohistochemical markers. The treatment of choice is radical excision with wide margins, achieving satisfactory results.
皮肤平滑肌肉瘤是罕见的平滑肌恶性肿瘤。我们在此报告两例皮肤平滑肌肉瘤,一例起源于真皮,另一例起源于皮下血管,经组织学和免疫组织化学证实。两例均采用广泛手术切除治疗,其中一例出现局部复发。随访期间未发现转移。对于具有梭形细胞恶性组织学特征的病变,应考虑平滑肌肉瘤。在大多数情况下,需要用特定的免疫组织化学标志物进行组织学鉴别。首选的治疗方法是广泛切缘的根治性切除,可取得满意的效果。