神经元丝氨酸消旋酶调节成年小鼠海马体中的细胞外 D-丝氨酸水平。
Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus.
作者信息
Ishiwata Sayuri, Umino Asami, Balu Darrick T, Coyle Joseph T, Nishikawa Toru
机构信息
Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
出版信息
J Neural Transm (Vienna). 2015 Aug;122(8):1099-103. doi: 10.1007/s00702-015-1388-2. Epub 2015 Mar 18.
Abstract
In the hippocampus of mice lacking the gene for serine racemase (SR), a D-serine synthesizing enzyme, in the CaMKIIα-expressing neurons, we observed a significant decrease in the extracellular concentration of D-serine, a coagonist for the N-methyl-D-aspartate type glutamate receptor (NMDAR), and NMDAR hypofunction as revealed by diminished extracellular taurine concentrations after an intra-hippocampal NMDA infusion when compared to the wild type controls. Therefore, the neuronal SR could regulate the extracellular D-serine signaling responsible for NMDAR activation in the hippocampus.
摘要
在缺乏丝氨酸消旋酶（SR，一种D-丝氨酸合成酶）基因的小鼠海马体中，在表达CaMKIIα的神经元中，我们观察到D-丝氨酸（N-甲基-D-天冬氨酸型谷氨酸受体（NMDAR）的一种协同激动剂）的细胞外浓度显著降低，并且与野生型对照相比，海马体内注入NMDA后细胞外牛磺酸浓度降低，这表明NMDAR功能减退。因此，神经元SR可能调节负责海马体中NMDAR激活的细胞外D-丝氨酸信号传导。
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