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膝关节骨关节炎:与关节软骨结构和功能的临床联系

Knee osteoarthritis: Clinical connections to articular cartilage structure and function.

作者信息

Brody Lori Thein

机构信息

University of Wisconsin Hospital and Clinics, Research Park Clinic, 621 Science Drive, Madison, WI 53711, USA; Orthopaedic and Sports Science, Rocky Mountain University of Health Professions, 122 East 1700 South, Bldg. C, Provo, UT 84606, USA.

出版信息

Phys Ther Sport. 2015 Nov;16(4):301-16. doi: 10.1016/j.ptsp.2014.12.001. Epub 2014 Dec 12.

Abstract

Articular cartilage is a unique biphasic material that supports a lifetime of compressive and shear forces across joints. When articular cartilage deteriorates, whether due to injury, wear and tear or normal aging, osteoarthritis and resultant pain can ensue. Understanding the basic science of the structure and biomechanics of articular cartilage can help clinicians guide their patients to appropriate activity and loading choices. The purpose of this article is to examine how articular cartilage structure and mechanics, may interact with risk factors to contribute to OA and how this interaction provides guidelines for intervention choices This paper will review the microstructure of articular cartilage, its mechanical properties and link this information to clinical decision making.

摘要

关节软骨是一种独特的双相材料,可在关节处承受一生的压缩力和剪切力。当关节软骨退化时,无论是由于损伤、磨损还是正常衰老,都可能引发骨关节炎并导致疼痛。了解关节软骨的结构和生物力学的基础科学知识,有助于临床医生指导患者做出适当的活动和负荷选择。本文的目的是探讨关节软骨的结构和力学如何与风险因素相互作用,从而导致骨关节炎,以及这种相互作用如何为干预选择提供指导。本文将回顾关节软骨的微观结构、其力学特性,并将这些信息与临床决策联系起来。

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