Khawaja Muhammad Rizwan, Minturn John T, Spittler A John, Chiorean E Gabriela
Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Midwest Eye Institute, Indianapolis, IN, USA.
Hematol Oncol Stem Cell Ther. 2015 Dec;8(4):176-80. doi: 10.1016/j.hemonc.2015.02.002. Epub 2015 Mar 10.
Approximately 20% of patients with colorectal cancer have metastatic disease at time of diagnosis, and another 25-35% develop metastases during the course of their disease. Liver, peritoneum, and lungs are the most common sites of metastases. We report the case of a 60-year-old female who presented with ocular metastasis 4 years after her initial curative-intent treatment for T3N1M0 rectal adenocarcinoma. After local eye radiation therapy, she received palliative systemic chemotherapy and enjoyed a good quality of life for 32 months before succumbing to progressive disease. Ocular metastasis of colorectal cancer is rare. When present, it usually occurs in the setting of diffuse hematogenous spread. In addition to local therapy, systemic chemotherapy should also be considered.
大约20%的结直肠癌患者在诊断时已有转移性疾病，另有25%-35%的患者在病程中发生转移。肝脏、腹膜和肺是最常见的转移部位。我们报告了一例60岁女性病例，她在接受T3N1M0直肠腺癌的初始根治性治疗4年后出现眼部转移。在局部眼部放射治疗后，她接受了姑息性全身化疗，并在死于疾病进展前享受了32个月的良好生活质量。结直肠癌的眼部转移很少见。一旦出现，通常发生在弥漫性血行播散的情况下。除了局部治疗外，还应考虑全身化疗。
