PIAS3是一种STAT3抑制剂，与胃癌患者的生存率呈显著负相关。
PIAS3, an inhibitor of STAT3, has intensively negative association with the survival of gastric cancer.
作者信息
Li Jingwu, Cui Jianzhong, Zhang Jinghua, Liu Yuanting, Han Longcai, Jia Chunliang, Deng Jingyu, Liang Han
机构信息
Section of Surgery Teaching and Research, Hebei Medical University Shijiazhuang, Hebei Province, China ; Department of Surgical Oncology, Tangshan People's Hospital Tangshan, Hebei Province, China.
Section of Surgery Teaching and Research, Hebei Medical University Shijiazhuang, Hebei Province, China.
出版信息
Int J Clin Exp Med. 2015 Jan 15;8(1):682-9. eCollection 2015.
OBJECTIVE
The present study was conducted to elucidate the prognostic prediction value of the expression of the protein inhibitor of activated signal transducer and activators of transcription 3 (PIAS3) in gastric cancer (GC).
METHODS
We detected the expression of PIAS3 in GC tissue, adjacent non-tumor tissue, GC cell lines, and GES-1 cell line. Besides, both clinicopathological data and follow-up records were obtained for patients' survival analyses.
RESULTS
We showed that both protein and mRNA expression of PIAS3 in GC tissue were significantly lower than those in adjacent non-tumor tissue, respectively. Besides, the relative mRNA expression value of PIAS3 in each of GC cell lines was also much lower than that in GES-1 cell line. With multivariate survival analyses, PIAS3 protein expression in GC tissues, and status of lymph node metastasis were identified to be the independently prognostic predictors of GC by using the Cox regression with bootstrapping method.
CONCLUSIONS
Lower expression of PIAS3 protein, indicating the poor survival of GC, is a potential marker for prediction the prognosis of patients.
目的
本研究旨在阐明活化信号转导子和转录激活子3蛋白抑制剂（PIAS3）的表达在胃癌（GC）中的预后预测价值。
方法
我们检测了PIAS3在GC组织、癌旁非肿瘤组织、GC细胞系和GES-1细胞系中的表达。此外，获取了临床病理数据和随访记录用于患者生存分析。
结果
我们发现，GC组织中PIAS3的蛋白和mRNA表达分别显著低于癌旁非肿瘤组织。此外，各GC细胞系中PIAS3的相对mRNA表达值也远低于GES-1细胞系。通过多因素生存分析，采用Bootstrapping法的Cox回归分析确定GC组织中PIAS3蛋白表达和淋巴结转移状态为GC的独立预后预测因素。
结论
PIAS3蛋白表达降低表明GC患者生存较差，是预测患者预后的一个潜在标志物。
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