Eifler Karolin, Vertegaal Alfred C O
Department of Molecular Cell Biology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Trends Biochem Sci. 2015 Dec;40(12):779-793. doi: 10.1016/j.tibs.2015.09.006. Epub 2015 Oct 22.
Protein conjugation with Small ubiquitin-like modifier (SUMOylation) has critical roles during cell cycle progression. Many important cell cycle regulators, including many oncogenes and tumor suppressors, are functionally regulated via SUMOylation. The dynamic SUMOylation pattern observed throughout the cell cycle is ensured via distinct spatial and temporal regulation of the SUMO machinery. Additionally, SUMOylation cooperates with other post-translational modifications to mediate cell cycle progression. Deregulation of these SUMOylation and deSUMOylation enzymes causes severe defects in cell proliferation and genome stability. Different types of cancer were recently shown to be dependent on a functioning SUMOylation system, a finding that could be exploited in anticancer therapies.
蛋白质与小泛素样修饰物的缀合（SUMO化）在细胞周期进程中起关键作用。许多重要的细胞周期调节因子，包括许多癌基因和肿瘤抑制因子，通过SUMO化进行功能调节。通过SUMO机制独特的空间和时间调节，确保了在整个细胞周期中观察到的动态SUMO化模式。此外，SUMO化与其他翻译后修饰协同作用以介导细胞周期进程。这些SUMO化和去SUMO化酶的失调会导致细胞增殖和基因组稳定性出现严重缺陷。最近发现不同类型的癌症依赖于正常运作的SUMO化系统，这一发现可用于抗癌治疗。
