Thompson W D, Campbell R, Evans T
J Pathol. 1985 Jan;145(1):27-37. doi: 10.1002/path.1711450103.
Fibrin deposition and removal is a feature common to major pathological processes such as wound healing, chronic inflammation and tumour invasion: processes involving the ingrowth of new blood vessels. Low molecular weight fibrin degradation products (MW less than 50,000) are now shown to induce angiogenesis in the chick chorioallantoic membrane (CAM). This effect has also been shown by new quantitative assays to be associated with stimulation of both DNA and protein synthesis. Autoradiography indicates that all cell types in the CAM are stimulated to divide, and it is proposed that fibrin degradation products are a pathological growth factor.
纤维蛋白的沉积和清除是伤口愈合、慢性炎症和肿瘤侵袭等主要病理过程的共同特征，这些过程都涉及新血管的长入。现已表明，低分子量纤维蛋白降解产物（分子量小于50,000）可诱导鸡胚绒毛尿囊膜（CAM）血管生成。新的定量分析也表明，这种作用与DNA和蛋白质合成的刺激有关。放射自显影显示，CAM中的所有细胞类型均受到刺激而分裂，因此有人提出纤维蛋白降解产物是一种病理性生长因子。
