Edelstam G, Fredens K, Venge P
Department of Obstetrics and Gynecology, Uppsala University, Sweden.
Inflammation. 1994 Aug;18(4):361-71. doi: 10.1007/BF01534434.
Increased numbers of eosinophilic granulocytes and eosinophil degranulation have been observed in various inflammatory conditions. Biopsies from the fallopian tubes of 28 patients were examined for the content of eosinophilic granulocytes. Peritoneal fluids (PF) from 89 patients were analyzed for the concentrations of eosinophilic granulocytes and the granule protein eosinophil cationic protein (ECP). The ECP levels in the PF were substantially elevated during genital inflammation (P < 0.001). Furthermore, one week after laparotomy for adhesiolysis there were both increased PF-ECP levels (P < 0.01) and raised concentrations of eosinophilic granulocytes (P < 0.001) when compared to the reference group. Staining of the biopsies with monoclonal antibodies revealed an increased total number as well as a number of activated eosinophilic granulocytes in specimens from adhesions and sactosalpinx compared to specimens from normal fimbriae. The findings indicate that eosinophilic granulocytes may have a possible role in the fibrotic process of pelvic adhesion disease.
在各种炎症状态下，已观察到嗜酸性粒细胞数量增加和嗜酸性粒细胞脱颗粒现象。对28例患者的输卵管活检组织进行了嗜酸性粒细胞含量检查。对89例患者的腹腔液（PF）进行了嗜酸性粒细胞浓度和颗粒蛋白嗜酸性粒细胞阳离子蛋白（ECP）分析。在生殖器炎症期间，PF中的ECP水平显著升高（P < 0.001）。此外，与参照组相比，剖腹手术行粘连松解术后一周，PF-ECP水平升高（P < 0.01），嗜酸性粒细胞浓度也升高（P < 0.001）。与正常伞端标本相比，用单克隆抗体对活检组织进行染色显示，粘连和输卵管积脓标本中的嗜酸性粒细胞总数以及活化嗜酸性粒细胞数量均增加。这些发现表明，嗜酸性粒细胞可能在盆腔粘连疾病的纤维化过程中发挥作用。
