Li Ting, Wang Zhen, Zhang Mingliang, Zhang Hui-Jun, Wen Ting-Bin
Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, Fujian, P. R. China.
Chem Commun (Camb). 2015 Apr 21;51(31):6777-80. doi: 10.1039/c5cc01412c.
An unusual Rh/Cu-catalyzed synthesis of pyrido[2,1-a]indoles starting from 1-(pyridin-2-yl)-1H-indoles and γ-substituted propargyl alcohols was presented. The multi-step cascade transformations formally involve the cleavage of two C-H, three C-C, and one C-N bonds with concomitant construction of two C-H, four C-C, and one C-N bonds with excellent chemoselectivity in one-pot reaction.
本文介绍了一种从1-(吡啶-2-基)-1H-吲哚和γ-取代的炔丙醇出发，通过Rh/Cu催化的不同寻常的合成吡啶并[2,1-a]吲哚的方法。多步串联转化形式上涉及两个C-H键、三个C-C键和一个C-N键的断裂，同时在一锅反应中以优异的化学选择性构建两个C-H键、四个C-C键和一个C-N键。
