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内部抗原与免疫网络。

Internal antigen and immune network.

作者信息

Kohler H, Muller S, Bona C

出版信息

Proc Soc Exp Biol Med. 1985 Feb;178(2):189-95. doi: 10.3181/00379727-178-41996a.

DOI:10.3181/00379727-178-41996a
PMID:2578671
Abstract

The network hypothesis postulates the existence of internal idiotopic structures which mimic nominal antigens. Experimental evidence for idiotope internal antigen is presented and its implication for the Network hypothesis is discussed. The exploitation of the internal idiotope antigens (or preparation of vaccines) is a realistic possibility.

摘要

网络假说假定存在模仿天然抗原的内部独特型结构。本文提供了关于独特型内部抗原的实验证据,并讨论了其对网络假说的意义。利用内部独特型抗原(或制备疫苗)是切实可行的。

相似文献

1
Internal antigen and immune network.内部抗原与免疫网络。
Proc Soc Exp Biol Med. 1985 Feb;178(2):189-95. doi: 10.3181/00379727-178-41996a.
2
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The idiotypic network: internal images of rabbit immunoglobulin allotopes.独特型网络:兔免疫球蛋白同种异型表位的内部影像
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引用本文的文献

1
Isolation of alpaca anti-idiotypic heavy-chain single-domain antibody for the aflatoxin immunoassay.为黄曲霉毒素免疫分析分离羊驼抗独特型重链单域抗体。
Anal Chem. 2013 Sep 3;85(17):8298-303. doi: 10.1021/ac4015885. Epub 2013 Aug 21.
2
Immunoglobulin with complementary paratope and idiotope.具有互补互补位和独特型位的免疫球蛋白。
J Exp Med. 1986 Apr 1;163(4):787-96. doi: 10.1084/jem.163.4.787.
3
Biological mimicry of antigenic stimulation: analysis of the in vivo antibody responses induced by monoclonal anti-idiotypic antibodies.
抗原刺激的生物学模拟:单克隆抗独特型抗体诱导的体内抗体反应分析。
Immunology. 1988 Jan;63(1):1-8.
4
Cross-reacting idiotypes on cryoprecipitating rheumatoid factor.冷沉淀类风湿因子上的交叉反应独特型
Springer Semin Immunopathol. 1988;10(1):35-55. doi: 10.1007/BF02054022.
5
Development and characterization of an anti-idiotype antibody to the capsular polysaccharide of Neisseria meningitidis serogroup C.针对脑膜炎奈瑟菌C群荚膜多糖的抗独特型抗体的研制与特性分析
Infect Immun. 1988 May;56(5):1120-7. doi: 10.1128/iai.56.5.1120-1127.1988.
6
Idiotypic self binding of a dominant germline idiotype (T15). Autobody activity is affected by antibody valency.优势种系独特型(T15)的独特型自身结合。自身抗体活性受抗体价的影响。
J Exp Med. 1987 May 1;165(5):1332-43. doi: 10.1084/jem.165.5.1332.
7
Antiidiotypic antibody vaccine in murine Schistosomiasis mansoni comprising the internal image of antigen.
J Clin Invest. 1989 Mar;83(3):912-20. doi: 10.1172/JCI113976.
8
Discrimination of the determinant specificity of two competitive Semliki Forest virus neutralizing monoclonal antibodies by anti-idiotypic antibodies.利用抗独特型抗体鉴别两种竞争性塞姆利基森林病毒中和单克隆抗体的决定簇特异性
Arch Virol. 1988;100(1-2):115-20. doi: 10.1007/BF01310913.