Kohler H, Muller S, Bona C
Proc Soc Exp Biol Med. 1985 Feb;178(2):189-95. doi: 10.3181/00379727-178-41996a.
The network hypothesis postulates the existence of internal idiotopic structures which mimic nominal antigens. Experimental evidence for idiotope internal antigen is presented and its implication for the Network hypothesis is discussed. The exploitation of the internal idiotope antigens (or preparation of vaccines) is a realistic possibility.
网络假说假定存在模仿天然抗原的内部独特型结构。本文提供了关于独特型内部抗原的实验证据,并讨论了其对网络假说的意义。利用内部独特型抗原(或制备疫苗)是切实可行的。