Ishiwata R, Iwasa M
Department of Complex Systems Science, Graduate School of Information Science, Nagoya University, Nagoya 4648601, Japan.
Phys Biol. 2015 Mar 19;12(2):026004. doi: 10.1088/1478-3975/12/2/026004.
This report presents a simple model that describes the motion of a single Dictyostelium discoideum cell exposed to a traveling wave of cyclic adenosine monophosphate (cAMP). The model incorporates two types of responses to stimulation by cAMP: the changes in the polarity and motility of the cell. The periodic change in motility is assumed to be induced by periodic cAMP stimulation on the basis of previous experimental studies. Consequently, the net migration of the cell occurs in a particular direction with respect to wave propagation, which explains the migration of D. discoideum cells in aggregation. The wave period and the difference between the two response times are important parameters that determine the direction of migration. The theoretical prediction compared with experiments presented in another study. The transition from the single-cell state of the population of D. discoideum cells to the aggregation state is understood to be a specific example of spontaneous breakage of symmetry in biology.
本报告提出了一个简单模型，该模型描述了单个盘基网柄菌细胞在受到环状单磷酸腺苷（cAMP）行波刺激时的运动。该模型纳入了细胞对cAMP刺激的两种反应类型：细胞极性和运动性的变化。基于先前的实验研究，假定运动性的周期性变化是由周期性cAMP刺激诱导的。因此，细胞的净迁移相对于波传播发生在特定方向上，这解释了盘基网柄菌细胞在聚集过程中的迁移。波周期和两种反应时间之间的差异是决定迁移方向的重要参数。将理论预测与另一项研究中呈现的实验进行了比较。盘基网柄菌细胞群体从单细胞状态到聚集状态的转变被理解为生物学中对称性自发破缺的一个具体例子。
