Dallon J C, Othmer H G
Mathematics Institute, Warwick University, Coventry, CV4 7AL, U.K.
J Theor Biol. 1998 Oct 21;194(4):461-83. doi: 10.1006/jtbi.1998.0766.
We developed a mathematical model of cell-to-cell-signalling in Dictyostelium discoideum that predicts the cAMP signal seen by individual cells in early aggregation. The model employs two cells on a plane and is designed to predict the space-time characteristics of both the extracellular cAMP signal seen by one cell when a nearby cell relays, and the intracellular cAMP response produced by the stimulus in the receiving cell. The effect of membrane bound phosphodiesterase is studied and it is shown that cells can orient effectively even in its absence. Our results give a detailed picture of how the spatio-temporal characteristics of the extracellular signal can be transduced into a time- and space-dependent intracellular gradient, and they suggest a plausible mechanism for orientation in a natural chemotactic wave.
我们构建了一个盘基网柄菌细胞间信号传导的数学模型，该模型可预测早期聚集过程中单个细胞所感知的cAMP信号。此模型采用平面上的两个细胞，旨在预测当附近细胞进行信号传递时，一个细胞所感知的细胞外cAMP信号的时空特征，以及刺激在接收细胞中产生的细胞内cAMP反应。我们研究了膜结合磷酸二酯酶的作用，结果表明即使在其不存在的情况下，细胞仍能有效地定向。我们的研究结果详细描绘了细胞外信号的时空特征如何转化为依赖时间和空间的细胞内梯度，并且为在自然趋化波中的定向提供了一种合理的机制。
