Duray P H, Mark E J, Barwick K W, Madri J A, Strom R L
Arch Pathol Lab Med. 1985 Jan;109(1):30-4.
Atrioventricular node congenital polycystic tumor, a lesion that causes heart block and sudden unexpected death, has been postulated to arise from the lymphatics, foregut endoderm, cardiac mesoderm, and mesothelium since its initial description in 1911. No theory concerning the histogenesis of this tumor has been completely satisfactory, either from an embryologic or a clinical standpoint. Biologic studies including cell culture systems from the lesions as well as optimal ultrastructural examination have been compromised due to postmortem autolysis. We studied four examples of this entity by standard histochemical stains for mucopolysaccharides, and by modified immunohistochemical labeling for carcinoembryonic antigen, factor VIII, and keratin. Results suggest an origin from foregut endoderm. The lesion has not been reported to be outside the region of the atrioventricular junction, but was demonstrated in the thymus gland in one of our cases.
房室结先天性多囊性肿瘤是一种可导致心脏传导阻滞和意外猝死的病变，自1911年首次被描述以来，一直被推测起源于淋巴管、前肠内胚层、心脏中胚层和间皮。从胚胎学或临床角度来看，关于这种肿瘤组织发生的理论都不尽人意。由于死后自溶，包括来自病变的细胞培养系统以及最佳超微结构检查在内的生物学研究受到了影响。我们通过对黏多糖的标准组织化学染色以及对癌胚抗原、因子VIII和角蛋白的改良免疫组织化学标记，研究了该实体的四个病例。结果提示其起源于前肠内胚层。该病变此前未见有发生于房室交界区以外部位的报道，但在我们的一个病例中，肿瘤出现在胸腺内。
