Albuquerque Verônica Batista de, Araújo Marcelo Augusto de, Ferreira Gabriel Thadeu Nogueira Martins, Fonseca Mariana Werneck, Arruda André Moreira Martins, ShiChen Lu, Oliva Valéria Nobre Leal de Souza
Department of Veterinary Medicine, Faculty of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
Faculty of Veterinary Medicine and Animal Science, UFMS, Campo Grande, MS, Brazil.
Acta Cir Bras. 2015 Mar;30(3):222-38. doi: 10.1590/S0102-8650201500300000010.
To investigate cardiorespiratory effects and serum concentration of ropivacaine combined with morphine at different doses.
Sixteen healthy adult female dogs weighting 9.8 ± 4.1 kg were included in the study. Twenty minutes after being premedicated with acepromazine and midazolam, the animals were randomly assigned to receive an epidural injection according to each group: RM0.15 = ropivacaine + morphine (0.15 mg kg(-1)) and RM0.2 = ropivacaine + morphine (0.2 mg kg(-1)). Variables recorded consisted of: heart rate and cardiac rhythm, respiratory rate, oxyhemoglobin saturation, inspired oxygen fraction, end-tidal carbon dioxide tension, systolic, mean and diastolic arterial pressures, serum cortisol, plasma ropivacaine and morphine.
SAP, MAP and DAP were significantly increased at TPR in RM0.15 but returned to normal values at the end of the procedure. Arterial pH was decreased in T30 and TESu in both groups and also returned to acceptable ranges at TR. Both PaO2 and PaCO2 were increased along the duration period of the epidural blockade (T30 and TESu) and returned to acceptable values at TR. Serum cortisol was lower at TB, T30 and TR when compared to TESu.
The procedures were performed safely and minimal changes in cardiovascular and respiratory variables.
研究不同剂量罗哌卡因联合吗啡的心肺效应及血清浓度。
16只体重9.8±4.1千克的健康成年雌性犬纳入本研究。用乙酰丙嗪和咪达唑仑进行预处理20分钟后,根据分组将动物随机分配接受硬膜外注射:RM0.15=罗哌卡因+吗啡(0.15毫克/千克)和RM0.2=罗哌卡因+吗啡(0.2毫克/千克)。记录的变量包括:心率和心律、呼吸频率、氧合血红蛋白饱和度、吸入氧分数、呼气末二氧化碳分压、收缩压、平均动脉压和舒张压、血清皮质醇、血浆罗哌卡因和吗啡。
RM0.15组在T30时收缩压、平均动脉压和舒张压显著升高,但在手术结束时恢复到正常值。两组在T30和TESu时动脉pH值均降低,在TR时也恢复到可接受范围。在硬膜外阻滞期间(T30和TESu),动脉血氧分压和二氧化碳分压均升高,并在TR时恢复到可接受值。与TESu相比,TB、T30和TR时血清皮质醇较低。
手术安全进行,心血管和呼吸变量变化最小。