由水溶性柱[5]芳烃和赖氨酸衍生物构建的用于可控药物释放的谷胱甘肽和pH响应型药物递送系统。
GSH- and pH-responsive drug delivery system constructed by water-soluble pillar[5]arene and lysine derivative for controllable drug release.
作者信息
Wu Xuan, Li Yan, Lin Chen, Hu Xiao-Yu, Wang Leyong
机构信息
Key Laboratory of Mesoscopic Chemistry of MOE, Center for Multimolecular Organic Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
出版信息
Chem Commun (Camb). 2015 Apr 21;51(31):6832-5. doi: 10.1039/c5cc01393c.
Novel GSH- and pH-responsive supramolecular vesicles constructed by an amphiphilic inclusion complex formed from water-soluble pillar[5]arene and lysine derivative have been successfully developed, which can efficiently encapsulate anticancer drug MTZ and show rapid MTZ-release in a simulated acidic tumor environment with high GSH concentration, and exhibit potent antitumor activity.
由水溶性柱[5]芳烃和赖氨酸衍生物形成的两亲性包合物构建的新型谷胱甘肽和pH响应超分子囊泡已成功开发，其能有效包封抗癌药物MTZ，并在高谷胱甘肽浓度的模拟酸性肿瘤环境中快速释放MTZ，且展现出强大的抗肿瘤活性。
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