Monda L, Wick M R
Hum Pathol. 1985 Mar;16(3):287-93. doi: 10.1016/s0046-8177(85)80016-2.
In an effort to investigate the utility of immunostaining for S-100 protein in the differential diagnosis of chondroblastoma, the expression of S-100 protein in nine chondroblastomas was compared with that in six giant cell tumors, six aneurysmal bone cysts, four giant cell reparative granulomas, six cases of fibrous dysplasia, two cases of osteitis fibrosa cystica, two nonossifying fibromas, and one clear cell chondrosarcoma. Five enchondromas, three typical chondrosarcomas, and one mesenchymal chondrosarcoma were also included as control tumors. The proliferating stromal cells in seven of the nine chondroblastomas stained for S-100 protein, as did the lacunar chondrocytes in all of the enchondromas and chondrosarcomas and rare stromal cells in the clear cell chondrosarcoma. In contrast, none of the other tumefactive bone lesions included in this study demonstrated S-100 protein immunoreactivity. These results suggest that immunohistochemical assessment of S-100 protein may be a method for diagnostically separating chondroblastoma from pathologic entities that could be histologically confused with it in the presence of limited biopsy material. However, clear cell chondrosarcoma would appear to represent an exception to this general statement.
为了研究S - 100蛋白免疫染色在软骨母细胞瘤鉴别诊断中的作用，将9例软骨母细胞瘤中S - 100蛋白的表达与6例骨巨细胞瘤、6例动脉瘤样骨囊肿、4例巨细胞修复性肉芽肿、6例骨纤维结构不良、2例囊性纤维性骨炎、2例非骨化性纤维瘤及1例透明细胞软骨肉瘤中的表达进行了比较。另外，还纳入了5例内生软骨瘤、3例典型软骨肉瘤及1例间叶性软骨肉瘤作为对照肿瘤。9例软骨母细胞瘤中有7例的增殖性基质细胞S - 100蛋白染色阳性，所有内生软骨瘤和软骨肉瘤中的陷窝状软骨细胞以及透明细胞软骨肉瘤中的罕见基质细胞S - 100蛋白染色也呈阳性。相反，本研究纳入的其他肿瘤性骨病变均未显示S - 100蛋白免疫反应性。这些结果表明，在活检材料有限的情况下，S - 100蛋白的免疫组化评估可能是一种将软骨母细胞瘤与可能在组织学上与之混淆的病理实体进行诊断性区分的方法。然而，透明细胞软骨肉瘤似乎是这一普遍观点的一个例外。
