Somkijrungroj Thanapong, Pearlman Joel A, Gonzales John A
*Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, California; †Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; and ‡Retinal Medical Group, Sacramento, California.
Retin Cases Brief Rep. 2015 Summer;9(3):214-7. doi: 10.1097/ICB.0000000000000141.
To describe the progressive, peripheral linear streaks of the equatorial retina, known as Schlaegel lines, in multifocal choroiditis and panuveitis (MCP).
A case report of a 13-year-old girl with MCP showed progression of retinal linear streaks. Extensive systemic and ophthalmologic investigations were performed.
Linear streaks in MCP showed progression before the institution of immunomodulatory treatment. Infrared imaging showed hyperreflectivity of the lesions with surrounding hyporeflectivity. Optical coherence tomography showed elevated and irregular hyperreflectivity of the retinal pigment epithelium and choroidal hyperreflectivity. These findings, including the clinical progression before immunomodulatory therapy and negative systemic evaluation for infectious entities, are consistent with MCP.
Patients with linear streaks in the setting of atypical MCP can progress and should be treated with adequate systemic corticosteroids and immunomodulatory agents. This case is unique in that it shows the evolution of Schlaegel lines using a multimodal imaging approach. Multimodal imaging can provide ancillary evidence of disease activity.
描述多灶性脉络膜炎和全葡萄膜炎(MCP)中赤道视网膜的进行性周边线性条纹,即施莱格尔线。
一名患有MCP的13岁女孩的病例报告显示视网膜线性条纹进展。进行了广泛的全身和眼科检查。
MCP中的线性条纹在免疫调节治疗开始前显示进展。红外成像显示病变处高反射,周围低反射。光学相干断层扫描显示视网膜色素上皮隆起且不规则高反射,脉络膜也呈高反射。这些发现,包括免疫调节治疗前的临床进展以及对感染性疾病的全身评估阴性,均与MCP相符。
非典型MCP情况下出现线性条纹的患者病情可能进展,应使用适当的全身皮质类固醇和免疫调节药物进行治疗。该病例独特之处在于它使用多模态成像方法展示了施莱格尔线的演变。多模态成像可为疾病活动提供辅助证据。